Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ.

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Jing ZhouJunfang Qin

Abstract

Chronic stress and related hormones are key in cancer progression. Peroxisome proliferator-activated receptor γ (PPARγ) and its agonists was reported that inducing anti-tumor effect. However, the function of PPARγ in pro-tumorigenic effects induced by chronic stress in breast cancer remains unknown. Herein, we have characterized a novel role of PPARγ and vascular endothelial growth factor (VEGF)/fibroblast growth factor 2 (FGF2) signals in breast cancer promoted by chronic stress. We performed experiments in vivo and in vitro and used bioinformatics data to evaluate the therapeutic potential of PPARγ in breast cancer promoted by stress. Chronic stress significantly inhibited the PPARγ expression and promoted breast cancer in vivo. VEGF/FGF2-mediated angiogenesis increased in the chronic stress group compared to the control group. PPARγ agonist pioglitazone (PioG) injection offset the pro-tumorigenic effect of chronic stress. Moreover, specific β2-adrenergic receptor (β2R) antagonist ICI11-8551 inhibited the effect of chronic stress. In vitro, norepinephrine (NE) treatment had a similar tendency to chronic stress. The effect of NE was mediated by the β2R/adenylate cyclase signaling pathway and suppressed by PioG. PPARγ suppresse...Continue Reading

References

Sep 23, 2000·Nature·P Carmeliet, R K Jain
Nov 20, 2002·Herz·Gerd Wallukat
Jun 20, 2006·Cardiovascular Research·Masuko Ushio-Fukai
Mar 11, 2010·Journal of Experimental & Clinical Cancer Research : CR·Takayuki YoshizakiToshikatsu Okumura
Dec 5, 2012·Brain, Behavior, and Immunity·Steven W Cole
Aug 6, 2013·Breast Cancer Research and Treatment·Edoardo BotteriSara Gandini
Jun 24, 2014·Nature Medicine·Timo HeidtMatthias Nahrendorf
Jul 2, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyung A KwonHyo-Jin Kim
Oct 24, 2015·International Journal of Colorectal Disease·S AmorM Granado
Aug 25, 2016·Salud pública de México·Cristina P Pineda-BelmontesLizbeth López-Carrillo
Mar 30, 2017·PPAR Research·Melody ChiuTerry D Hinds
Jun 8, 2017·Seminars in Cell & Developmental Biology·Jennifer N Moloney, Thomas G Cotter
Nov 10, 2017·Science Translational Medicine·Monique B NilssonJohn V Heymach
Feb 8, 2019·Critical Reviews in Food Science and Nutrition·Ayesha NasirSanabil Yaqoob

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Methods Mentioned

BETA
BioAssay
flowcytometry
xenograft
flow cytometry

Software Mentioned

SigmaStat
FlowJo

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