Activation of 5-HT(2C) receptors reduces the locomotor and rewarding effects of nicotine

Psychopharmacology
A J GrottickGuy A Higgins

Abstract

Various compounds believed to selectively interact with the 5-HT(2C) receptor have been demonstrated to alter the functioning of ascending dopamine systems. We postulated that this functional interaction may extend to the behavioural effects of drugs of abuse whose rewarding properties are critically dependent upon mesolimbic DA activity. The present studies focussed on interactions between 5-HT(2C) receptor function and behaviours either supported or induced by nicotine. The effect of Ro 60-0175, a 5-HT(2C) agonist, was assessed for its ability to modify 1) nicotine-induced locomotor activity in nicotine-treated rats, 2) lever pressing maintained by either food or IV administration of nicotine, and 3) the development of nicotine-induced hyperactivity. The specificity of this effect was further measured in locomotor activity studies by additional administration of the selective 5-HT(2C) antagonist SB 242,084. Ro 60-0175 (0.3-3 mg/kg SC) dose-dependently reduced nicotine-induced activity, an effect which was reversed by SB 242,084 (0.5 mg/kg IP), thus confirming receptor selectivity of the response. Responding both for food and nicotine on an FR5TO1 min schedule of reinforcement was reduced by Ro 60-0175 (0.1-1 mg/kg) with propo...Continue Reading

Citations

Feb 19, 2005·Psychopharmacology·Aska HayashiKeiji Miyata
Mar 23, 2013·Psychopharmacology·Katharine A BrennanPenelope Truman
Nov 19, 2003·European Journal of Pharmacology·Guy A Higgins, Paul J Fletcher
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·Renee L Hayslett, Yousef Tizabi
Sep 18, 2013·Trends in Pharmacological Sciences·Guy A HigginsPaul J Fletcher
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Vincenzo Di MatteoEnnio Esposito
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Pallab SethSandra E File
Sep 6, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J De VryK R Jentzsch
Dec 24, 2003·Drug Discovery Today·John F CryanAthina Markou
Jun 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stella DrachevaWilliam M Byne
Dec 23, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Guy A HigginsPaul J Fletcher
Aug 14, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Noelle C AnastasioKathryn A Cunningham
Jul 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul J FletcherGuy A Higgins
Aug 12, 2014·Pharmacology, Biochemistry, and Behavior·Amir H RezvaniEdward D Levin
Jan 12, 2010·Drug and Alcohol Dependence·Maria IordanidouVangelis G Manolopoulos
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Jun 13, 2008·Addictive Behaviors·Joseph R DiFranza, W W Sanouri A Ursprung
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Aug 1, 2006·Trends in Pharmacological Sciences·Christian P Müller, Robert J Carey
Jul 28, 2005·Pharmacology, Biochemistry, and Behavior·Renee L Hayslett, Yousef Tizabi
Apr 29, 2014·Behavioural Brain Research·Christian P Müller, Judith R Homberg
Apr 15, 2015·ACS Chemical Neuroscience·Guy A Higgins, Paul J Fletcher
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Apr 23, 2013·Pharmacology, Biochemistry, and Behavior·Shinichi OginoHiroyuki Ito
Feb 16, 2010·Neuropharmacology·Magdalena ZaniewskaMałgorzata Filip

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