Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1

The Journal of Physiology
Paco S Herson, M L Ashford

Abstract

1. Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a non-selective cation channel. The channel opened is characterized by a linear current-voltage relation with a conductance of approximately 70 pS and very slow kinetics (of the order of seconds). 2. Cells are protected against the alloxan-induced channel opening and consequent cell depolarization by the presence of H2O2 and hydroxyl radical scavengers. 3. The free radical-activated non-selective cation channel is not operative in isolated patches but can be activated by the application of beta-NAD+ to the cytoplasmic aspect of the membrane.

References

Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Nov 1, 1986·Pflügers Archiv : European journal of physiology·G TrubeT Ohno-Shosaku
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D Pipeleers, M Van de Winkel
May 1, 1986·The Journal of Endocrinology·C A CarringtonC N Hales
Dec 1, 1984·Diabetologia·G L WilsonB T Mossman
Jan 1, 1993·Free Radical Research Communications·J M Gutteridge

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Citations

Jul 19, 2005·Pflügers Archiv : European journal of physiology·S McNulty, E Fonfria
Jun 14, 2005·Pflügers Archiv : European journal of physiology·Frank J P KühnAndreas Lückhoff
Feb 26, 1999·Biochemical Pharmacology·D JanjicC B Wolheim
May 27, 2003·Cell Calcium·Anne-Laure PerraudAndrew M Scharenberg
Apr 28, 1999·Free Radical Biology & Medicine·J SandersonG Williamson
Mar 27, 2002·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·L F BarrosJ Castro
Nov 22, 2000·The Biochemical Journal·G DrewsP Krippeit-Drews
Oct 5, 2010·The Journal of Biological Chemistry·Felipe SimonAndrés Stutzin
Sep 26, 2007·The Journal of General Physiology·John StarkusReinhold Penner
Nov 18, 2009·The Journal of General Physiology·Jianyang DuLixia Yue
Dec 16, 1998·The Journal of Physiology·P Krippeit-DrewsG Drews
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J RozmanB Zorko
May 19, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jia JiaPaco S Herson
May 28, 2004·American Journal of Physiology. Cell Physiology·Felipe SimonAndrés Stutzin
Sep 27, 2003·American Journal of Physiology. Cell Physiology·Robert KraftChristian Harteneck
Sep 17, 1999·The Journal of Biological Chemistry·P MaechlerC B Wollheim
Jul 31, 2010·Expert Opinion on Therapeutic Targets·Lin-Hua JiangDavid J Beech
Mar 7, 2003·American Journal of Physiology. Renal Physiology·Babu J Padanilam
Mar 28, 2006·The Journal of Biological Chemistry·Olivera GrubishaJohn M Denu
Dec 8, 2010·The Journal of Physiology·Adriana Sumoza-Toledo, Reinhold Penner
Jan 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Madhav Bhatia
Jul 27, 2000·Endothelium : Journal of Endothelial Cell Research·S H SuhB Nilius

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