PMID: 6592031Jun 1, 1984Paper

Activation of acute-phase responses by intrapreoptic injections of endogenous pyrogen in guinea pigs

Brain Research Bulletin
C M BlatteisT A Mashburn

Abstract

The acute-phase reaction (APR) is the concatenation of events that develops in response to infectious or other acute inflammatory stimuli. It includes fever and changes in plasma trace metal and glycoprotein levels. Endogenous pyrogen (EP) is believed to be the mediator of the APR. It acts within the preoptic-anterior hypothalamus (PO) to initiate fever; prostaglandins E (PGE) may modulate this action. To determine whether the nonfebrile responses to EP also are mediated by the PO and through PGE, guinea pigs were injected bilaterally intra-PO (iPO) with homologous EP (1 microliter) or PGE2 (0.1 microgram), and their colonic temperatures (Tco) and plasma iron (Fe), zinc (Zn), copper (Cu), and N-acetylneuraminic acid (NANA) levels were measured. For comparison, EP (2 ml) also was injected intraperitoneally (IP). Heat-denatured EP (delta EP) or pyrogen-free saline (PFS) was the corresponding control. Fevers were induced by IP EP (1.0 +/- 0.1 degrees C [mean +/- SD]), iPO EP (1.1 +/- 0.2 degrees C), and iPO PGE2 (1.4 +/- 0.2 degrees C); neither delta EP nor PFS was pyrogenic. Plasma Fe and Zn levels were decreased significantly after IP EP, but unchanged after iPO EP and PGE2. Plasma Cu and NANA levels were elevated significantly ...Continue Reading

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Citations

Oct 1, 1984·Pflügers Archiv : European journal of physiology·T A MashburnC M Blatteis
Nov 1, 1987·Pflügers Archiv : European journal of physiology·A MorimotoN Murakami
Apr 1, 1995·Physiology & Behavior·M S ExtonA J Husband
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·M S ExtonA J Husband
Nov 1, 1985·Peptides·M S AhmedC M Blatteis
Dec 1, 1985·Brain Research Bulletin·R A AhokasC M Blatteis
Jul 1, 1987·Brain Research Bulletin·W S HunterR A Ahokas
Apr 1, 1989·Brain Research Bulletin·N Quan, C M Blatteis
Jun 1, 1990·Brain Research Bulletin·F J MiñanoR D Myers
Jan 1, 1988·The International Journal of Neuroscience·C M Blatteis
Jul 1, 1988·The International Journal of Neuroscience·I Baciu

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