PMID: 7993306Sep 1, 1994Paper

Activation of adenosine A1 receptors in the nucleus accumbens impairs inhibitory avoidance memory

Behavioral and Neural Biology
H J NormileR A Barraco

Abstract

Potent and highly selective adenosine A1 and A2 receptor agonists were bilaterally injected into the nucleus accumbens of mice 10 min prior to inhibitory avoidance training. Retention of the inhibitory avoidance response was assessed 24 h after training. Intra-ACB activation of A1 receptors, but not A2a receptor activation, significantly impaired the performance of mice during the subsequent retention test. Furthermore, the retention deficit produced by activation of A1 receptors was significantly attenuated by pretreating mice with a highly selective A1 receptor antagonist. These findings suggest that endogenous adenosine may modulate information processing in the ventral striatum via adenosine A1 receptors.

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Citations

Mar 3, 2004·Neurobiology of Learning and Memory·Elsa Regina VinadéDiogo Onofre Souza
Jan 1, 1997·Life Sciences·A de Mendonça, J A Ribeiro
Oct 8, 2003·Behavioural Brain Research·Undine E LangDavid P Wolfer
Jun 28, 2001·Brain Research Bulletin·M S GevaerdC Da Cunha
Dec 28, 1999·Brain Research. Brain Research Reviews·J L Moreau, G Huber
Mar 8, 2006·Experimental Neurology·Jian Hong WangMaarten van den Buuse
Jun 19, 1996·Annals of the New York Academy of Sciences·B J Yates

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