Activation of alloreactive natural killer cells is resistant to cyclosporine

Transplantation
E PeterssonG Hedlund

Abstract

We have previously shown that cytotoxic T lymphocytes (CTL) with alloreactivity were induced when Wistar Furth (WF; RT1u) rats were immunized with allogeneic Brown Norway (BN; RT1n) cells. In contrast, when BN rats were immunized with WF cells, the allospecific response was confined to alloreactive natural killer (NK) cells, and no CTL activity was observed. In this study, the effect of cyclosporine (CsA) on the activation of alloreactive NK cells in vivo was analyzed. Distinct peritoneal effector cells from rats immunized with allogenic cells with or without concomitant CsA and/or interleukin (IL) 2 treatment were tested for specific cytolytic activity. Furthermore, the presumptive role of NK cells in rejection immunity was addressed in a cardiac graft model. The results showed that doses of CsA that completely inhibited the activation of alloreactive CTL, only marginally affected the activation of alloreactive NK cells. We also showed that CsA treatment failed to prolong graft survival in BN recipients of WF hearts. Treatment of BN rats with CsA/IL-2 during immunization with allogeneic WF cells resulted in concomitant induction of alloreactive NK cells and alloreactive CTL. We have demonstrated that CsA failed to suppress the...Continue Reading

References

Apr 1, 1992·Immunology Today·S L Schreiber, G R Crabtree
Aug 1, 1992·Immunology Today·L MorettaK Kärre
Jul 1, 1992·Immunology Today·T Dalianis, L Ahrlund-Richter
Oct 1, 1992·Current Opinion in Immunology·M D Pescovitz
Jan 1, 1992·Annual Review of Immunology·Y Y YuM Bennett
Oct 1, 1991·Current Opinion in Immunology·R Lechler, G Lombardi
Jan 1, 1991·European Journal of Clinical Pharmacology·A Lindholm
Dec 1, 1988·The Journal of Experimental Medicine·E CicconeL Moretta
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·W M Yokoyama
Mar 1, 1993·Archives of Surgery·C Chandler, E Passaro
Oct 1, 1995·Current Opinion in Immunology·L L Lanier
Jan 10, 1997·Cellular Immunology·E PeterssonG Hedlund

❮ Previous
Next ❯

Citations

Mar 30, 2006·Transplantation·William H KitchensJoren C Madsen
Jan 15, 2008·Transplantation·Lu-En WaiSheri M Krams
Oct 23, 2010·PloS One·Olivier MorteauChristopher A O'Callaghan
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D N EissensI Joosten
May 1, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Claire DendleStephen Holdsworth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.