Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines

Life Sciences
Géraldine LemaireRoger Rahmani

Abstract

Many persistent pesticides have been implicated in reproductive and developmental adverse effects, in man and wildlife. It has been hypothesized that these so-called xeno-hormones could upset the endocrine system function by binding to human estrogen receptor alpha and beta (ERalpha, beta) and thus be responsible for the higher incidence of breast and cervical cancer, infertility and endometriosis. In this report, forty-nine pesticides were tested for ERalpha and beta activation or inhibition in stable reporter cell lines, HELN ERalpha and ERbeta. Stable transfection of the ERalpha and ERbeta constructs together with an estrogen reporter luciferase vector into the HeLa cell line resulted in two estradiol-sensitive cell lines. In our model, fifteen of the tested pesticides were found to agonize the ERalpha-mediated transcription in a dose-dependent manner and DDT, trans-nonachlor, chlordane, fenvalerate and toxaphene were also capable to activate ERbeta. Antagonistic activities toward hERalpha and hERbeta were shown in three (carbaryl, pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) and seven (chlordecone, methoxychlor, carbaryl, endosulfan, endrin, dieldrin, aldrin) pesticides, respectively. Remarkably chlordecone and ...Continue Reading

References

Jan 1, 1986·Journal of Steroid Biochemistry·S GreenP Chambon
Jan 7, 1988·Nature·V GiguèreR M Evans
Apr 1, 1987·Archives of Toxicology·S P SaxenaJ Chandra
Nov 1, 1993·Reproductive Toxicology·L M WaltersV P Eroschenko
Oct 1, 1995·Environmental Health Perspectives·T Colborn
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
May 1, 1996·Critical Reviews in Toxicology·A C Nimrod, W H Benson
Nov 1, 1996·Bulletin of Environmental Contamination and Toxicology·E V Minelli, M L Ribeiro
Oct 30, 1996·Molecular and Cellular Endocrinology·S F ArnoldJ A McLachlan
Jan 1, 1997·Toxicology and Applied Pharmacology·M MooreP Balaguer
Feb 6, 1997·Nature·J AshbyJ P Sumpter
Jul 1, 1997·Analytical Biochemistry·A JoyeuxJ C Nicolas
Mar 27, 1999·Archives of Environmental Health·L Torres-ArreolaM López-Cervantes
Apr 3, 1999·Toxicology and Industrial Health·R L CooperT E Stoker
May 20, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·J LeglerB van der Burg
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z WeihuaJ A Gustafsson
Sep 12, 2000·Journal of Exposure Analysis and Environmental Epidemiology·L F ElviaS Carillo Constanza
Jan 11, 2001·Journal of Medicinal Chemistry·S R StaufferJ A Katzenellenbogen
Feb 13, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J MatthewsT Zacharewski
Mar 9, 2002·Toxicology and Applied Pharmacology·Helle Raun AndersenEva Cecilie Bonefeld-Jørgensen
May 3, 2002·The Journal of Biological Chemistry·Meng-Min LiuPeter J Kushner
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Haiyan ChenXinru Wang
Nov 6, 2002·Biochemical Pharmacology·Xavier CoumoulRobert Barouki
Sep 23, 2003·Endocrinology·Heather A HarrisJames C Keith
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anders StrömJan-Ake Gustafsson
Mar 3, 2004·Molecular Interventions·Jason Matthews, Jan-Ake Gustafsson
Apr 15, 2004·Toxicology and Applied Pharmacology·Géraldine LemaireRoger Rahmani
Apr 15, 2004·Life Sciences·Joohee JungTsutomu Nishihara
Nov 19, 2004·Biochemical Pharmacology·Géraldine LemaireRoger Rahmani
Apr 1, 2005·Journal of Toxicology and Environmental Health. Part a·E GomezC Casellas
Apr 21, 2005·Analytical Biochemistry·Arnaud PillonJean-Claude Nicolas
Mar 24, 2006·Biochemical Pharmacology·Aurélie EscandePatrick Balaguer

❮ Previous
Next ❯

Citations

Jul 26, 2012·Angiogenesis·Nicolas ClereSébastien Faure
Jul 19, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·L RibonnetY Larondelle
Jun 30, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher J MartyniukNancy D Denslow
Jan 22, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tessie PauloseJodi A Flaws
Feb 1, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Víctor BrizCristina Suñol
Dec 19, 2009·Environmental Health Perspectives·Mark P PurdueKatherine A McGlynn
Oct 12, 2012·Environmental Health Perspectives·Daniel M RotroffRichard S Judson
Feb 23, 2011·PloS One·Imran ShahDavid J Dix
Jul 22, 2011·International Journal of Environmental Research and Public Health·Wissem MnifBenoit Roig
Jan 10, 2014·American Journal of Epidemiology·Philippe KadhelSylvaine Cordier
Nov 15, 2011·Chronobiology International·Nermine O BastaRichard J Q McNally
Dec 12, 2012·Toxicology·Ezra J MremaClaudio Colosio
Oct 16, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Élyse Caron-BeaudoinJ Thomas Sanderson
Oct 24, 2013·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Patricia L Bishop, Catherine E Willett
May 4, 2007·Toxicology and Applied Pharmacology·Olga Leaños-CastañedaG Gold
Jul 3, 2015·Environmental Research·Nathalie CostetSylvaine Cordier
Feb 28, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Anne-Marie SaillenfaitJean-Philippe Sabaté
Jan 7, 2010·International Journal of Andrology·E SwedenborgJ-A Gustafsson
Sep 20, 2012·Journal of Environmental and Public Health·Sam De Coster, Nicolas van Larebeke
Jan 10, 2012·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S ChakrabartyB Senthilkumaran
Jan 28, 2015·Endocrine-related Cancer·Denise K ReavesJodie M Fleming
Dec 17, 2014·Acta Pharmacologica Sinica·Vanessa DelfosseWilliam Bourguet
Jul 14, 2016·Environmental Health : a Global Access Science Source·Vincent NedellecWilliam Dab
Aug 11, 2016·Chemical Research in Toxicology·Caroline L PintoPatience Browne
Dec 29, 2013·Environmental Science & Technology·Beate I EscherFrederic D L Leusch
Jun 23, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Luc MultignerPascal Blanchet
Jun 24, 2014·Osong Public Health and Research Perspectives·Jae-Hong ParkWon Jin Lee
Dec 3, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Belén Gómez-GiménezVicente Felipo
Oct 25, 2017·International Journal of Environmental Research and Public Health·Demetrios PetrakisAristides M Tsatsakis
Dec 21, 2017·Journal of Molecular Endocrinology·Yiyan WangRen-Shan Ge
May 6, 2015·Environmental Science and Pollution Research International·Luc MultignerSylvaine Cordier
Aug 12, 2009·Cellular and Molecular Life Sciences : CMLS·Elin SwedenborgJoëlle Rüegg

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