Activation of alpha 1-adrenoceptors is not essential for the mediation of ischaemic preconditioning in rat heart

Clinical and Experimental Pharmacology & Physiology
Eleni VasaraAntigone Lazou

Abstract

1. The aim of the present study was to clarify the role of alpha1-adrenoceptors in the mechanism of ischaemic preconditioning (IP). 2. Rat isolated perfused hearts were either non- preconditioned, preconditioned with 5 min ischaemia or treated for 5 min with alpha1-adrenoceptor agonists (50 micromol/L phenylephrine; 0.1, 0.5 and 1 micromol/L methoxamine) before being subjected to 45 min of sustained ischaemia followed by 60 min reperfusion. 3. Within each of the above protocols, hearts were divided into groups to which alpha1-adrenoceptor antagonists (prazosin, 5'-methyl urapidil and chloroethylclonidine (CEC)) were administered. Functional recovery and infarct size were used as indices of the effects of ischaemia. Ischaemic contracture characteristics and maximal diastolic pressure during reflow were also assessed. 4. Blockade of alpha(1)-adrenoceptors with prazosin or the subtype-selective antagonists 5'-methyl urapidil and CEC did not abolish the protective effect of IP with respect to both functional recovery and infarct size reduction. 5. Protection afforded by phenylephrine was attenuated in hearts treated with prazosin or the alpha(1B)-adrenoceptor- selective antagonist CEC, but not in those treated with the alpha(1A)-ad...Continue Reading

References

Feb 1, 1992·Circulation Research·G J Gross, J A Auchampach
Oct 1, 1992·Journal of Molecular and Cellular Cardiology·A C Cave, D J Hearse
Apr 1, 1990·Circulation Research·R J SchottW Schaper
Aug 1, 1990·Circulation·G C LiB R Lucchesi
Jan 1, 1995·Circulation Research·M B MitchellA Banerjee
Nov 1, 1993·Cardiovascular Research·T IwamotoH F Downey
Aug 1, 1995·Journal of Molecular and Cellular Cardiology·D P JenkinsD M Yellon
Sep 1, 1996·Circulation Research·G Brooks, D J Hearse
Jun 1, 1996·Journal of Molecular and Cellular Cardiology·J P Headrick
Oct 1, 1996·Circulation Research·Z YuG I Fishman
Oct 7, 1996·Biochimica Et Biophysica Acta·K YoshidaS Kawashiama
Jan 1, 1997·Journal of Molecular and Cellular Cardiology·C P BainesJ M Downey
Apr 16, 1998·Cardiovascular Research·L R Dekker
Dec 2, 1998·Basic Research in Cardiology·M S Sumeray, D M Yellon
Apr 18, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A EfstathiouA Lazou

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Citations

Apr 14, 2006·Basic Research in Cardiology·Efstathios K IliodromitisDimitrios Th Kremastinos
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Eleni VasaraAntigone Lazou
May 12, 2009·Acta Anaesthesiologica Scandinavica·M HeinR Rossaint
Jan 11, 2014·Journal of Cardiovascular Pharmacology·Bruno BuchholzRicardo J Gelpi

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