PMID: 8604018Mar 1, 1996Paper

Activation of alveolar macrophage TNF and MCP-1 expression in vivo by a synthetic peptide of C-reactive protein

Journal of Leukocyte Biology
B P BarnaS D Deodhar

Abstract

Administration of multilamellar vesicles (MLV) encapsulating a synthetic peptide (RS-83277) derived from human C-reactive protein (CRP) augments anti-tumor activity of murine alveolar macrophages and reduces established pulmonary metastases of experimental tumors. To explore mechanisms involved in these phenomena, we investigated cytokine and integrin (CDllb) expression of bronchoalveolar lavage (BAL)-derived alveolar macrophages in control (blank MLV) and RS-83277-MLV-treated C57BI mice. Alveolar macrophage production of tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant bioactivity increased at 48 h after treatment with RS-83277-MLV but not control MLV. Chemoattractant activity was neutralized by antibody to monocyte chemoattractant protein-1 (MCP-1), but not irrelevant immunoglobulin G(IgG). Changes were reflected by augmented TNF-alpha and MCP-1 mRNA levels in pulmonary tissue and enhanced CD11b expression on mononuclear leukocytes derived from total lung tissue, but not on BAL-derived alveolar macrophages. Results suggest that RS-83277-MLV treatment is associated with activation of alveolar macrophage TNF-alpha and MCP-1 production and up-regulation of adhesion molecules on pulmonary mononuclear leukocyte...Continue Reading

Citations

Jan 18, 2006·Clinical and Experimental Immunology·D S PouniotisC F McDonald
Feb 2, 1999·The Journal of Experimental Medicine·S A JonesG M Fuller
Sep 7, 2001·Environmental Health Perspectives·K DonaldsonW MacNee
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven K LundyNicholas W Lukacs
Mar 25, 2016·Protein Science : a Publication of the Protein Society·Aitor Blanco-MíguezBorja Sánchez
Oct 13, 2005·Journal of Cardiovascular Pharmacology·Liangqi XieXian Wang

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