Activation of AMP-activated protein kinase induce expression of FoxO1, FoxO3a, and myostatin after exercise-induced muscle damage

Biochemical and Biophysical Research Communications
Kihyuk LeeK Nakazato

Abstract

AMP-activated protein kinase (AMPK) has been shown to regulate protein metabolism in skeletal muscle. We previously found that levels of Forkhead box proteins, FoxO1 and FoxO3a, and myostatin in rat gastrocnemius increased after exercise-induced muscle damage (EIMD). Eccentric muscle contractions (ECs), defined as elongation of muscle under tension, were used for inducing EIMD. The objective of this study was to clarify whether AMPK participates in activation and expression of FoxO proteins and myostatin in rat gastrocnemius muscle after EIMD. Wistar rats were randomly assigned into the following three groups; CON (n = 6), 180ECs group (ankle angular velocity, 180°/s; n = 6), and 30ECs group (ankle angular velocity, 30°/s; n = 6). 20 ECs were conducted with percutaneous electrical stimulation of gastrocnemius and simultaneous forced dorsiflexion of ankle joint (from 0° to 45°). To evaluate activation of AMPK, we measured the phosphorylated states of AMPK and acetyl CoA carboxylase. For evaluation of the direct relationships of AMPK and other proteins, we also examined contents of FoxOs and myostatin with stimulation of L6 myotube with AMPK agonist, 5 -aminoimidazole -4 -carboxamide -1-β-d-ribofuranoside (AICAR) (0.1, 0.5, 1, 1....Continue Reading

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Nov 13, 2013·Muscle & Nerve·Kihyuk LeeKoichi Nakazato

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Citations

Sep 13, 2020·Journal of Cachexia, Sarcopenia and Muscle·Jacob L BrownHolly Van Remmen
Aug 9, 2019·Journal of Gastroenterology·Maryam EbadiAldo J Montano-Loza
Apr 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ChenPeter X Ma
May 16, 2019·Physiological Reports·Evgeny A LysenkoOlga L Vinogradova
Feb 15, 2020·The Journal of Poultry Science·Takaoki SaneyasuHiroshi Kamisoyama
Nov 17, 2020·Expert Review of Gastroenterology & Hepatology·Giovanni MarascoMatteo Renzulli
Jan 11, 2021·Journal of Endocrinological Investigation·W-X SunS-G Pang
Mar 4, 2021·BMC Musculoskeletal Disorders·Xiaohong LyuShinong Pan
Oct 27, 2021·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jun Hyun BaeWook Song

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