Activation of an alternative NF-kappaB pathway in skeletal muscle during disuse atrophy

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
R Bridge HunterSusan C Kandarian

Abstract

Although cytokine-induced nuclear factor kappaB (NF-kappaB) pathways are involved in muscle wasting subsequent to disease, their potential role in disuse muscle atrophy has not been characterized. Seven days of hind limb unloading led to a 10-fold activation of an NF-kappaB-dependent reporter in rat soleus muscle but not the atrophy-resistant extensor digitorum longus muscle. Nuclear levels of p50 were markedly up-regulated, c-Rel was moderately up-regulated, Rel B was down-regulated, and p52 and p65 were unchanged in unloaded solei. The nuclear IkappaB protein Bcl-3 was increased. There was increased binding to an NF-kappaB consensus oligonucleotide, and this complex bound antibodies to p50, c-Rel, and Bcl-3 but not other NF-kappaB family members. Tumor necrosis factor alpha (TNF-alpha) and TNF receptor-associated factor 2 protein were moderately down-regulated. There was no difference in p38, c-Jun NH(2)-terminal kinase or Akt activity, nor were activator protein 1 or nuclear factor of activated T cell-dependent reporters activated. Thus, whereas several NF-kappaB family members are up-regulated, the prototypical markers of cytokine-induced activation of NF-kappaB seen with disease-related wasting are not evident during disus...Continue Reading

References

Apr 1, 1988·Molecular and Cellular Biology·D B DurandG R Crabtree
Jan 1, 1994·Annual Review of Cell Biology·U SiebenlistK Brown
Oct 1, 1994·Surgical Oncology·N J EspatL L Moldawer
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y LavrovskyN G Abraham
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Jan 15, 1997·Genes & Development·E M SchwarzI M Verma
Aug 1, 1997·The American Journal of Physiology·D L AllenV R Edgerton
Jan 31, 1998·The Journal of Clinical Investigation·M A SovakG E Sonenshein
Jan 31, 1998·The Journal of Biological Chemistry·D L Bundy, T W McKeithan
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Jul 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Y P LiM B Reid
Nov 25, 1998·Journal of Cellular Biochemistry·T K MacLachlan, A Giordano
Feb 19, 1999·BioTechniques·E BloughK Esser
Apr 9, 1999·Science·K TakedaS Akira
May 18, 1999·The American Journal of Physiology·D G PetersS C Kandarian
Jul 27, 1999·Current Opinion in Chemical Biology·A J Lewis, A M Manning
Aug 13, 1999·The American Journal of Physiology·M R BergmanB J Holycross
Sep 1, 1999·International Journal of Experimental Pathology·A K RainaM A Smith
Sep 15, 1999·Nature·J A Romashkova, S S Makarov
Dec 22, 1999·The American Journal of Physiology·H Mitchell-Felton, S C Kandarian
Dec 22, 1999·Oncogene·M Barkett, T D Gilmore
Mar 25, 2000·Mechanisms of Ageing and Development·Y LavrovskyA K Roy
Mar 25, 2000·Molecular and Cellular Biology·C ChenC Gélinas
Jun 15, 2000·The American Journal of Pathology·J FrenetteJ G Tidball
Aug 5, 2000·Free Radical Biology & Medicine·Y M Janssen-HeiningerP A Baeuerle

❮ Previous
Next ❯

Citations

Feb 5, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Foteini Mourkioti, Nadia Rosenthal
Jun 25, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hong LiAshok Kumar
Jun 30, 2005·Acta Neuropathologica·K M HaslbeckD Heuss
Oct 20, 2006·Apoptosis : an International Journal on Programmed Cell Death·Emidio E PistilliStephen E Alway
Dec 17, 2008·Biogerontology·Stephen DoddAndrew Judge
Aug 10, 2010·Cell Stress & Chaperones·Marko Balan, Marius Locke
Feb 28, 2013·Cell Stress & Chaperones·Evan J H LewisCatherine E Amara
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J M SteffenW K Milsom
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D A KoebelJ M Steffen
Aug 30, 2005·The International Journal of Biochemistry & Cell Biology·Marc Bartoli, Isabelle Richard
May 17, 2005·The International Journal of Biochemistry & Cell Biology·Paola CostelliFrancesco M Baccino
Aug 10, 2005·The International Journal of Biochemistry & Cell Biology·David J Glass
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Frederick M IveyRichard F Macko
Feb 22, 2003·Journal of Biomechanics·Pietro E di Prampero, Marco V Narici
Aug 13, 2013·Nutrition Research Reviews·Hugues MagneDominique Dardevet
Aug 21, 2004·Journal of Neurotrauma·Eric LandryPierre A Guertin
Jan 5, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Thomas W BufordDarryn S Willoughby
Oct 2, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Darin Van GammerenSusan C Kandarian
Jun 17, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephen L DoddAndrew R Judge
Aug 2, 2002·Exercise and Sport Sciences Reviews·Susan C Kandarian, Eric J Stevenson
Feb 6, 2010·Critical Care Medicine·Melissa A ChambersMichael B Reid
Apr 12, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Valentina Guasconi, Pier Lorenzo Puri
Nov 3, 2010·Biological Reviews of the Cambridge Philosophical Society·Kristian Gundersen
Jul 8, 2003·The Journal of Physiology·Eric J StevensonSusan C Kandarian
Sep 22, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Thomas W BufordDarryn S Willoughby
Jun 18, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jae-Sung YouYeon-Sook Lee
Feb 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marius Locke, Jocelyn Anderson
May 18, 2012·American Journal of Physiology. Cell Physiology·Takuo YamakiSusan C Kandarian
Sep 14, 2010·American Journal of Respiratory and Critical Care Medicine·Sanford LevineMurat T Budak
Nov 17, 2004·The Journal of Clinical Investigation·R Bridge Hunter, Susan C Kandarian
Nov 3, 2006·The Journal of Clinical Investigation·Foteini MourkiotiNadia Rosenthal
Sep 6, 2007·The Journal of Clinical Investigation·Naoki SuzukiShin'ichi Takeda
Aug 17, 2011·BMC Musculoskeletal Disorders·Annabelle Z CaronGuillaume Grenier
Feb 4, 2014·PloS One·Evangeline W CornwellRobert W Jackman
Jun 21, 2008·Journal of Rehabilitation Research and Development·Frederick M IveyRichard F Macko

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