Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance

Molecular Plant-microbe Interactions : MPMI
X LiX Dong

Abstract

The Arabidopsis NPR1 protein is an essential regulatory component of systemic acquired resistance (SAR). Mutations in the NPR1 gene completely block the induction of SAR by signals such as salicylic acid (SA). An Arabidopsis mutant, snc1 (suppressor of npr1-1, constitutive 1), was isolated in a screen for suppressors of npr1-1. In the npr1-1 background, the snc1 mutation resulted in constitutive resistance to Pseudomonas syringae maculicola ES4326 and Peronospora parasitica Noco2. High levels of SA were detected in the mutant and shown to be required for manifestation of the snc1 phenotype. The snc1 mutation was mapped to the RPP5 resistance (R) gene cluster and the eds1 mutation that blocks RPP5-mediated resistance suppressed snc1. These data suggest that a RPP5-related resistance pathway is activated constitutively in snc1. This pathway does not employ NPR1 but requires the signal molecule SA and the function of EDS1. Moreover, in snc1, constitutive resistance is conferred in the absence of cell death, which is often associated with R-gene mediated resistance.

References

Jun 1, 1992·The Plant Cell·S UknesJ Ryals
May 5, 1995·Science·B J StaskawiczJ D Jones
Aug 1, 1993·The Plant Journal : for Cell and Molecular Biology·A Konieczny, F M Ausubel
Oct 1, 1996·The Plant Cell·K E Hammond-Kosack, J D Jones
May 2, 1997·Science·B BakerS P Dinesh-Kumar
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·N AartsJ E Parker
Mar 6, 1999·Current Opinion in Plant Biology·X Dong
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·A FalkJ E Parker
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangX Dong
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·K S CenturyB J Staskawicz
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·T P DelaneyJ A Ryals
Oct 1, 1996·The Plant Cell·A. F. Bent
Oct 1, 1996·The Plant Cell·J. A. RyalsM. D. Hunt
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·I RaskinW R Melander

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Citations

Oct 21, 2010·Plant Cell Reports·Thomas Merkle
Oct 16, 2008·Plant Molecular Biology·Tzuu-Fen Lee, Timothy W McNellis
Mar 11, 2008·Cell Host & Microbe·Jeffrey CaplanSavithramma P Dinesh-Kumar
Jan 26, 2012·Nature Reviews. Immunology·Steven H Spoel, Xinnian Dong
Jul 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zhaohai ZhuYuelin Zhang
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yu Ti ChengXin Li
Apr 3, 2010·Plant & Cell Physiology·Jacqueline Monaghan, Xin Li
Aug 11, 2012·Molecular Plant-microbe Interactions : MPMI·Heather L ShearerPierre R Fobert
Nov 6, 2007·Molecular Plant-microbe Interactions : MPMI·Yongqing LiJian Hua
Jul 5, 2008·Plant Physiology·Sandra GoritschnigXin Li
Jun 13, 2012·Plant Physiology·Daniel MarinoSusana Rivas
Nov 7, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Li WanBostjan Kobe
Apr 30, 2009·Annual Review of Phytopathology·A Corina VlotDaniel F Klessig
Apr 16, 2008·BMC Plant Biology·Hankuil Yi, Eric J Richards
Jan 5, 2011·PLoS Genetics·Hugo GermainXin Li
Oct 19, 2012·Journal of Experimental Botany·Geraint Parry
Jan 1, 2011·Journal of Pathogens·Virginia WoloshenXin Li
May 8, 2009·Bulletin of Environmental Contamination and Toxicology·Qiang XuLin Hao
Nov 26, 2009·Bulletin of Environmental Contamination and Toxicology·Qiang XuLin Hao

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