PMID: 698822Oct 6, 1978Paper

Activation of an inhibitory noradrenergic pathway projecting from the locus coeruleus to the cingulate cortex of the rat

Brain Research
N DillierH R Olpe

Abstract

Repetitive stimulation of the locus coeruleus evoked strong inhibition of the firing rate of about 50% of cells of the cingulate rat cortex. Forty per cent of the cells were not affected and 9% were excited by stimulation of the locus coeruleus. Pretreatment of the rats with reserpine and alpha-methyl-p-tyrosine drastically reduced the percentage of cells inhibited by locus coeruleus stimulation. The cells inhibited in response to stimulation of the locus coeruleus as well as those not inhibited were depressed by microiontophoretically applied norepinephrine. This inhibitory action of NE was observed in rats anesthetized either with urethane, chloral hydrate or with Nembutal. The transsynaptically elicited, as well as the norepinephrine elicited, depression of the cells' discharge rate was antagonized by the microiontophoretically applied beta-receptor blocking drug MJ 1999. These data suggest that the inhibitory action on cingulate cortical cells of locus coeruleus stimulation is mediated by the dorsal ascending noradrenergic pathway.

References

Jan 1, 1977·General Pharmacology·J W Phillis, G K Kostopoulos
Apr 1, 1976·Japanese Journal of Pharmacology·J H Austin, S Takaori
Dec 1, 1972·European Journal of Pharmacology·L M JordanJ W Phillis
May 1, 1974·The Journal of Comparative Neurology·V M PickelF E Bloom

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Citations

Jun 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·H R Olpe, W P Koella
Jan 1, 1985·European Journal of Clinical Pharmacology·W P Koella
Sep 1, 1986·Neuroscience and Behavioral Physiology·Z I Nanobashvili, S P Narikashvili
May 26, 1980·Brain Research·M E Corcoran, S T Mason
Jul 20, 1981·Brain Research·S J Fung, C D Barnes
Apr 11, 1980·European Journal of Pharmacology·H R Olpe, A Schellenberg
Nov 21, 1980·European Journal of Pharmacology·R C Meibach, S Maayani
May 18, 1987·Life Sciences·J F LipinskiC M Waternaux
Jan 1, 1987·Progress in Neuro-psychopharmacology & Biological Psychiatry·C W Harley
Dec 1, 1981·Brain Research Bulletin·L P Solano-FloresR Guevara-Aguilar
Dec 1, 1985·Brain Research Bulletin·R Guevara-AguilarM J Wayner
Apr 1, 1979·Behavioral and Neural Biology·P Ramm
Sep 17, 1993·Brain Research. Developmental Brain Research·E SundströmA Seiger
Jun 21, 2011·Expert Opinion on Investigational Drugs·Jolanda PrinsS Mechiel Korte
Jul 7, 1980·Brain Research·A Leppävuori, P T Putkonen
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·F E Bloom, L Y Koda
Jan 17, 2015·European Journal of Pharmacology·S Mechiel KorteBerend Olivier
Jan 1, 1988·Annals of the New York Academy of Sciences·A M ThierryJ Glowinski
Apr 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A SolomonS Chien
May 1, 1984·Stroke; a Journal of Cerebral Circulation·J A CapraroJ R Little
Jun 9, 1980·Brain Research·H S SingerD L Price

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