Activation of Antioxidative Functions by Radon Inhalation Enhances the Mitigation Effects of Pregabalin on Chronic Constriction Injury-Induced Neuropathic Pain in Mice

Oxidative Medicine and Cellular Longevity
Takahiro KataokaKiyonori Yamaoka

Abstract

Radon inhalation brings pain relief for chronic constriction injury- (CCI-) induced neuropathic pain in mice due to the activation of antioxidative functions, which is different from the mechanism of the pregabalin effect. In this study, we assessed whether a combination of radon inhalation and pregabalin administration is more effective against neuropathic pain than radon or pregabalin only. Mice were treated with inhaled radon at a concentration of 1,000 Bq/m(3) for 24 hours and pregabalin administration after CCI surgery. In mice treated with pregabalin at a dose of 3 mg/kg weight, the 50% paw withdrawal threshold of mice treated with pregabalin or radon and pregabalin was significantly increased, suggesting pain relief. The therapeutic effects of radon inhalation or the combined effects of radon and pregabalin (3 mg/kg weight) were almost equivalent to treatment with pregabalin at a dose of 1.4 mg/kg weight or 4.1 mg/kg weight, respectively. Radon inhalation and the combination of radon and pregabalin increased antioxidant associated substances in the paw. The antioxidant substances increased much more in radon inhalation than in pregabalin administration. These findings suggested that the activation of antioxidative functi...Continue Reading

References

Sep 1, 1975·The Journal of Clinical Investigation·R L BaehnerR B Johnston
Jan 1, 1980·Annual Review of Pharmacology and Toxicology·W J Dixon
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Feb 21, 2004·The Journal of Pain : Official Journal of the American Pain Society·Kiyonori YamaokaKatsuhiko Sugita
May 11, 2004·Journal of Radiation Research·Shuji KojimaHirokazu Ishida
Apr 17, 2008·Journal of Radiation Research·Hiroko NakatsukasaShuji Kojima

❮ Previous
Next ❯

Citations

Jan 6, 2021·International Journal of Molecular Sciences·Andreas MaierBenjamin Frey
Aug 10, 2021·Journal of Ethnopharmacology·Dominika Zajac

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.