PMID: 9434842Jan 22, 1998Paper

Activation of arylamines to mutagenic product(s) by two in vitro plant systems

Mutation Research
C ChiapellaM Llagostera

Abstract

Plant activation of three isomers of phenylenediamine o- m- and p-phenylenediamine, has been studied. Two in vitro plant systems have been used: Persea americana S117 with mixed-function oxidase (MFO) and peroxidase activities, and Zea mays S9 which contains only peroxidase activity. As genetic endpoint, the classical Salmonella tester strains. TA98 and TA100, their derivatives with high O-acetyltransferase levels (YG1024 and YG1029, respectively) and TA98/1.8-DNP6, deficient in this enzyme, have been assayed. Of the three isomers studied, only m-PDA was activated to mutagenic product(s) by both plant systems. This activation required the bacterial O-acetyltransferase activity to give frameshift mutagenic product(s), detected in TA98 and YG1024 strains. In all the assays the P americana system was more potent than the Z. mays system in activating m-PDA. A slight increase of the number of YG1029 revertants was detected when m-PDA was activated by P. americana, suggesting that this compound can be also converted into ultimate mutagenic product(s) that induce base-pair substitutions. m-PDA activation by Z. mays was dependent on the peroxidase activity of this system, but the activation produced by P. americana was totally dependen...Continue Reading

References

Dec 1, 1978·Environmental Health Perspectives·M J Plewa
Mar 1, 1991·Mutation Research·H U Aeschbacher, R J Turesky
Jan 1, 1990·Environmental and Molecular Mutagenesis·E D WagnerM J Plewa
Jan 1, 1987·Environmental and Molecular Mutagenesis·M A LhotkaJ M Gentile
May 1, 1968·Mutation Research·J Velemínský, T Gichner
May 1, 1983·Mutation Research·D M Maron, B N Ames

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Citations

Mar 27, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sandra Gómez-ArroyoJesús Javier Espinosa-Aguirre

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