PMID: 2497438Jan 1, 1989Paper

Activation of atrial muscarinic K+ channels by low concentrations of beta gamma subunits of rat brain G protein

Pflügers Archiv : European journal of physiology
Y KurachiM Ui

Abstract

Effects of G protein beta gamma subunits from rat brain on cardiac K+ channel was examined in single atrial cells of guinea-pig, using patch clamp techniques. We found that 10 pM concentration of rat brain beta gamma subunits preparation could activate the atrial muscarine receptor-gated K+ channel (IK.ACh). Neither the detergent, CHAPS, used to suspend beta gamma nor the boiled beta gamma preparation activated IK.ACh. Furthermore, preincubation of beta gamma subunits preparation in Mg2+-free solution, which easily inactivated alpha-GTP-gamma S, did not affect beta gamma-activation of IK.ACh. We concluded, therefore, that beta gamma subunits themselves can activate IK.ACh.

References

Nov 1, 1986·Pflügers Archiv : European journal of physiology·Y KurachiT Sugimoto
May 7, 1987·Nature·L Birnbaumer, A M Brown
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D E LogothetisD E Clapham
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C L Jelsema, J Axelrod

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Citations

Jan 1, 1994·Protein Science : a Publication of the Protein Society·E J Neer
Apr 1, 1990·Pflügers Archiv : European journal of physiology·Y KurachiT Sugimoto
Sep 1, 1992·Progress in Neurobiology·Y KurachiT Nakajima
Mar 1, 1994·Trends in Cardiovascular Medicine·Y Kurachi
Nov 11, 2003·Life Sciences·Masaru Ishii, Yoshihisa Kurachi
Sep 21, 2000·European Journal of Biochemistry·M D Mark, S Herlitze
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N DascalH A Lester
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·P KofujiH A Lester
May 19, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Shingo MurakamiYoshihisa Kurachi
Sep 21, 2013·Biophysical Journal·Shingo MurakamiYoshihisa Kurachi
Jan 1, 1990·Critical Reviews in Biochemistry and Molecular Biology·L BirnbaumerA M Brown
Aug 19, 2003·The Journal of Physiology·Yoshihisa Kurachi, Masaru Ishii
May 1, 1991·Hypertension·G E Breitwieser
Feb 3, 2019·The Journal of Biological Chemistry·Zack ZurawskiHeidi E Hamm
Sep 27, 2005·Physiological Reviews·Nina Wettschureck, Stefan Offermanns
Jan 21, 2010·Physiological Reviews·Hiroshi HibinoYoshihisa Kurachi
Dec 6, 2003·Pharmacological Reviews·Annette C Dolphin
Jan 20, 2001·The Journal of Biological Chemistry·S Corey, D E Clapham
Jan 13, 1995·The Journal of Biological Chemistry·A KovoorC Chavkin
Jul 25, 2019·Frontiers in Physiology·Yuriana Aguilar-SanchezJosefina Ramos-Franco
Oct 1, 1995·The American Journal of Physiology·Y Kurachi
Apr 1, 1990·Trends in Neurosciences·P C Sternweis, I H Pang

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