[Activation of axo-axonic synapses by serial impulses in afferent C fibres: the gate-control theory disproved by Manfred Zimmermann.].

Der Schmerz
R F Schmidt

Abstract

The gate-control theory of pain, as originally proposed by Melzack and Wall [8], is nothing but a hypothesis concerning the spinal processing of non-noxious and noxious afferent information. Its basic tenant is that the P cells (projecting neurons) convey noxious information to supraspinal pain systems only after a critical threshold of excitation has been passed, and that access to the P cells is controlled by the SG cells (cells of the substantia gelatinosa Rolandi) or, in other words, the SG cells act as the gate. Since the primary afferent fibres have monosynaptic connections with the P cells the gate can only operate-and this is the critical point of the whole hypothesis-via presynaptic inhibition exerted by axoaxonic contacts on these afferents (Fig. 1). The SG cells are excited by thick (low-threshold) afferent fibres, whereas input from fine (noxious) afferents has inhibitory effects. Low-threshold afferent input, therefore, produces little activation of P cells, since the collateral activation of the SG cells leads to vigorous activation of the presynaptic inhibitory gate (Fig. 1 a). But as soon as noxious input via fine afferent units inhibits the SG cells the gate will be opened and the P cells activated (Fig. 1b). P...Continue Reading

References

Mar 1, 1976·Brain : a Journal of Neurology·P W Nathan
Mar 1, 1978·Brain : a Journal of Neurology·P D Wall
May 24, 1968·Science·M Zimmermann
Jan 1, 1968·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·M Zimmermann
Nov 19, 1965·Science·R Melzack, P D Wall
Jul 11, 1969·Science·L VyklickýR E Burke
Aug 1, 1967·Brain Research·W JänigM Zimmermann
Oct 1, 1993·Pain·Hans-Georg Schaible, Blair D Grubb
May 1, 1962·The Journal of Physiology·J C ECCLESR F SCHMIDT
Jan 1, 1963·Journal of Neurophysiology·R F SCHMIDT, W D WILLIS
Aug 1, 1964·The Journal of Physiology·L M MENDELL, P D WALL

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Citations

Sep 10, 2015·Der Schmerz·K Messlinger, H O Handwerker

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