Activation of BLV transcription by NF-kappa B and Tax
Abstract
Bovine leukemia virus (BLV) is the causative agent of bovine leukosis, a naturally occurring fatal disease in cattle. BLV transcription is regulated by cellular transcription factors and the virally encoded oncoprotein Tax. In this report, we investigated the functional role of the putative NF-kappa B binding site recently identified in the BLV promoter. Our studies indicate that the kappa B binding motif acts as a functional enhancer in the presence of the cellular NF-kappa B proteins. Furthermore, the kappa B site together with a single 21-bp repeat confers strong activation of BLV transcription in the presence the NF-kappa B proteins and Tax. These results suggest that cellular NF-kappa B may be involved in the regulation of BLV transcription and activation of the virus from latency.
References
Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation
Citations
Related Concepts
Related Feeds
CREs: Gene & Cell Therapy
Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.