Activation of brain-derived neurotrophic factor signaling in the basal forebrain reverses acute sleep deprivation-induced fear memory impairments.

Brain and Behavior
Tao MaWei-Dong Mi

Abstract

The mechanisms underlying sleep deprivation-induced memory impairments and relevant compensatory signaling pathways remain elusive. We tested the hypothesis that increased brain-derived neurotrophic factor (BDNF) expression in the basal forebrain following acute sleep deprivation was a compensatory mechanism to maintain fear memory performance. Adult male Wistar rats were deprived of 6-hr total sleep from the beginning of the light cycle. The effects of sleep deprivation on BDNF protein expression and activation of downstream tropomyosin receptor kinase B (TrkB)/phospholipase C-γ1 (PLCγ1) signaling in the basal forebrain and fear memory consolidation were examined. BDNF or selective downstream TrkB receptor antagonist ANA-12 was further injected into the basal forebrain bilaterally to observe the changes in fear memory consolidation in response to modulation of the BDNF/TrkB signaling. Six hours of sleep deprivation-induced both short- and long-term fear memory impairments. Increased BDNF protein expression and TrkB and PLCγ1 phosphorylation in the basal forebrain were observed after sleep deprivation. Microinjection of BDNF into the basal forebrain partly reversed fear memory deficits caused by sleep deprivation, which were ac...Continue Reading

References

May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·I IzquierdoN G Bazan
Jan 1, 1997·Annual Review of Psychology·B J Everitt, T W Robbins
May 8, 1999·The American Journal of Physiology·T KushikataJ M Krueger
Dec 1, 1995·Journal of Sleep Research·D F Dinges
Jul 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R RoeslerM Bianchin
Dec 5, 2000·Brain Research·C Cirelli, G Tononi
Oct 9, 2002·Neuron·Liliana MinichielloMartin Korte
Apr 29, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maan Gee LeeBarbara E Jones
Jul 19, 2005·Nature Neuroscience·Newton H WooBai Lu
Aug 3, 2005·Nature Reviews. Neuroscience·Bai LuNewton H Woo
Oct 6, 2005·Learning & Memory·Mariana AlonsoJorge H Medina
Oct 28, 2005·Nature·Robert Stickgold
Jan 22, 2008·Nature Neuroscience·Tomoya MatsumotoYves-Alain Barde
Aug 19, 2008·Neurobiology of Learning and Memory·Tathiana A AlvarengaSergio Tufik
Jan 13, 2009·Nature Neuroscience·Jianmin YangBarbara L Hempstead
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael B DashGiulio Tononi
Jun 16, 2009·Neuroscience Research·Volkmar Lessmann, Tanja Brigadski
Aug 8, 2009·Sleep Medicine·Edward Bixler
Aug 14, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gabriele MusumeciLiliana Minichiello
Oct 23, 2009·Nature·Christopher G VecseyTed Abel
Feb 4, 2010·Sleep·Kristen L KnutsonDiane S Lauderdale
Feb 1, 2011·The Journal of Comparative Neurology·Patrick M FullerJun Lu
Apr 21, 2011·The Journal of Clinical Investigation·Maxime CazorlaDidier Rognan
Aug 31, 2011·Dementia and Geriatric Cognitive Disorders·Da Un JeongJin Woo Chang
Sep 8, 2012·Journal of Molecular Neuroscience : MN·Karem H AlzoubiBaraa E Abu Rashid
Dec 21, 2012·Nature Reviews. Neuroscience·Hyungju Park, Mu-ming Poo
May 22, 2013·Neuropharmacology·Pedro BekinschteinJorge H Medina
Jun 14, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura MascettiPierre Maquet
Dec 18, 2013·Journal of Neurophysiology·Liangfang Zhao, Eric S Levine
Mar 19, 2014·Cell·Yu FuMichael P Stryker
Dec 9, 2014·Cell Reports·Emmanuel EggermannCarl C H Petersen
Dec 17, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Adam J WatsonMarcos G Frank
Feb 15, 2015·Current Topics in Behavioral Neurosciences·Robbert HavekesTed Abel

❮ Previous
Next ❯

Citations

May 2, 2021·Journal of Cellular and Molecular Medicine·Yangliang YangHongwei Duan
Jul 3, 2021·Clocks & Sleep·Maria Neus Ballester RoigValérie Mongrain

❮ Previous
Next ❯

Key Resources (RRID) Mentioned

AB_10862052
AB_2721199
AB_2155125
AB_1310574
AB_10714566
AB_2687666
SCR_014280
SCR_002865

Software Mentioned

Quantity One Quantity One
SPSS

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.