PMID: 6107909Aug 1, 1980Paper

Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin

Proceedings of the National Academy of Sciences of the United States of America
D M KuhnW Lovenberg

Abstract

Tryptophan hydroxylase [tryptophan 5-monooxygenase, L-tryptophan,tetrahydropterin:oxygen oxidoreductase (5-hydroxylating), EC 1.14.16.4] is activated by phosphorylating conditions (ATP-Mg2+) in a calcium-dependent, cyclic AMP-independent manner. Addition to the phosphorylation reaction of certain antipsychotic drugs that bind to calmodulin, the heat-stable calcium-binding protein, prevents the activation of tryptophan hydroxylase by ATP-Mg2+ in a concentration-dependent fashion. External addition of purified calmodulin protects the enzyme from the drug-induced effects. Calmodulin-free tryptophan hydroxylase prepared by affinity chromatography on fluphenazine-Sepharose is not activated by ATP-Mg2+ whereas addition of calmodulin to calmodulin-free enzyme restores the responsiveness of the hydroxylase to ATP-MG2+ only in the presence of Ca2+. These results indicate that the activation of tryptophan hydroxylase by phosphorylating conditions is dependent on both calcium and calmodulin.

References

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Citations

Sep 1, 1987·Cellular and Molecular Neurobiology·D L Martin
Feb 15, 1991·Biochemical Pharmacology·P A JohansenD M Kuhn
Jul 9, 1987·European Journal of Pharmacology·M C Boadle-BiberT H Phan
Jan 1, 1988·The International Journal of Biochemistry·M Sawada, T Nagatsu
Nov 15, 1982·Life Sciences·D H Clouet, N Williams
Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·A V KulikovN K Popova
Jan 1, 1986·Neurochemistry International·M C Boadle-BiberT H Phan
May 11, 1992·Neuroscience Letters·M YoshiokaH Saito
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M LandtJ M McDonald
Dec 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G G ManjarrezJ Hernández
Nov 1, 1996·Journal of Neuroscience Methods·C D'SaD M Kuhn
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J P O'CallaghanW Lovenberg
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D R MarshakL J Van Eldik
Jun 15, 1981·Biochemical Pharmacology·C O Brostrom, D J Wolff
May 14, 1982·Biochemical and Biophysical Research Communications·A Vigny, J P Henry
Nov 1, 1984·Hypertension·M van den BuuseW de Jong
Jul 1, 1988·Journal of Neurochemistry·M C DarmonJ Mallet
Sep 1, 1981·Journal of Neurochemistry·A Vitto, A J Mandell
Oct 5, 2019·Nutrients·Chioma J IkonteSusan Hazels Mitmesser
May 1, 1986·Nutrition Reviews·W M Lovenberg
Jan 1, 1980·Annals of the New York Academy of Sciences·J P O'CallaghanW Lovenberg

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