Activation of Ca2+/calmodulin-dependent protein kinase II is involved in hyperosmotic induction of the human taurine transporter

FEBS Letters
H SatsuMakoto Shimizu

Abstract

We investigated the signaling pathways participating in hyperosmotic regulation of the human taurine transporter (TAUT) by using specific inhibitors of various intracellular signaling molecules. Among them, the specific inhibitor of calcium/calmodulin-dependent protein kinase II (Ca(2+)/CaM kinase II) completely repressed the hyperosmotic regulation of TAUT. The osmosensitive upregulation of TAUT was also significantly inhibited by calmodulin antagonists and calcium-chelators. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor. The activated form of Ca(2+)/CaM kinase II protein could only be detected in Caco-2 cells under hypertonic conditions.

References

Mar 11, 1992·The American Journal of Physiology·F L SmardoA Garcia-Perez
Jan 1, 1990·Current Topics in Cellular Regulation·R J Colbran, T R Soderling
Sep 24, 1982·Science·P H YanceyG N Somero
Aug 1, 1995·Current Opinion in Cell Biology·H M Kwon, J S Handler
Aug 24, 1995·Biochemical and Biophysical Research Communications·H M KwonJ S Handler
Aug 5, 1994·Science·Z Galcheva-GargovaR J Davis
Feb 1, 1994·The Journal of Experimental Zoology·M B Burg
Apr 1, 1993·Current Opinion in Cell Biology·H Schulman
Nov 1, 1996·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L M MatovcikJ R Goldenring
Jun 15, 1999·Biochimica Et Biophysica Acta·H SatsuM Shimizu
Sep 7, 1999·Journal of the American Society of Nephrology : JASN·X HanR W Chesney
Aug 3, 2000·Bioscience, Biotechnology, and Biochemistry·K IshizukaM Shimizu
Dec 18, 2001·American Journal of Physiology. Cell Physiology·Ohnn NahmH Moo Kwon
Jan 15, 2002·Advances in Experimental Medicine and Biology·I H Lambert, F V Sepúlveda
May 8, 2002·Nature Reviews. Molecular Cell Biology·Nia J BryantDavid E James
May 31, 2002·Bioscience, Biotechnology, and Biochemistry·Koji IshizukaMakoto Shimizu
Jul 18, 2003·Current Biology : CB·Makoto Kanzaki, Jeffrey E Pessin

❮ Previous
Next ❯

Citations

Feb 1, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Noriyuki TakaiHisashi Narahara
Jan 18, 2011·Biochimica Et Biophysica Acta·B J Gabert, D Kültz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.