Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice.

Journal of the American College of Cardiology
N Chin LaiH Kirk Hammond

Abstract

This study sought to evaluate whether increased left ventricular (LV) adenylyl cyclase VI (AC(VI)) expression, at a time when severe congestive heart failure (CHF) was present, would increase function of the actively failing heart. Increased LV AC(VI) content markedly reduces mortality and increases LV function after acute myocardial infarction (MI) in mice. However, the effects of increased cardiac AC(VI) content in the setting of severe heart failure caused by ischemic cardiomyopathy are unknown. Mice with cardiac-directed and regulated expression of AC(VI) underwent coronary artery ligation to induce severe CHF 5 weeks later. AC(VI) expression was then activated in 1 group (AC-On) but not the other (AC-Off). Multiple measures of LV systolic and diastolic function were obtained 5 weeks later, and LV samples were assessed for alterations in calcium and beta-adrenergic receptor signaling, apoptosis, and cardiac troponin I phosphorylation. The LV systolic and diastolic function was increased 5 weeks after activation of AC(VI) expression. Improved LV function was associated with normalization of cardiac troponin I phosphorylation and reduced apoptosis. Activation of cardiac AC(VI) expression in mice with ischemic cardiomyopathy a...Continue Reading

References

May 9, 2002·Circulation·David M RothH Kirk Hammond
Jun 14, 2002·Basic Research in Cardiology·Hamed BayatDavid M Roth
Jul 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Tong TangH Kirk Hammond
Sep 8, 2004·Journal of Molecular and Cellular Cardiology·Mary L RuehrMeredith Bond
Jun 6, 2006·Journal of Molecular and Cellular Cardiology·Valeriy TimofeyevNipavan Chiamvimonvat

❮ Previous
Next ❯

Citations

Dec 7, 2011·Current Heart Failure Reports·Razmig Garo Kratlian, Roger J Hajjar
Apr 27, 2012·Gene Therapy·T TangH Kirk Hammond
Apr 2, 2009·Nature Reviews. Drug Discovery·Sandra PierreKlaus Scholich
Oct 7, 2011·Journal of Cardiovascular Pharmacology·Michael S Kapiloff, Kshama D Chandrasekhar
Jun 22, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Aziz GuellichDorothy E Vatner
Oct 23, 2013·PloS One·Mei Hua GaoH Kirk Hammond
Apr 24, 2014·Pflügers Archiv : European journal of physiology·Aziz GuellichRodolphe Fischmeister
May 6, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shelley D MiyamotoCarmen C Sucharov
Dec 30, 2008·Heart Failure Reviews·Ali El-Armouche, Thomas Eschenhagen
Dec 25, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Tong Tang, H Kirk Hammond
Jun 5, 2012·Journal of Proteomics·Kumar KotloRobert S Danziger
Mar 1, 2011·Journal of Molecular and Cellular Cardiology·Mei Hua Gao, H Kirk Hammond
Jan 5, 2011·Biochemical and Biophysical Research Communications·Yasuo SuganoH Kirk Hammond
Feb 8, 2011·Progress in Pediatric Cardiology·Aisha H FrazierAnne M Murphy
Jul 30, 2009·Drug Discovery Today·Barbara PavanAlessandro Dalpiaz
Mar 12, 2015·Human Gene Therapy·N Chin LaiH Kirk Hammond
May 7, 2015·Oxidative Medicine and Cellular Longevity·Stephen F VatnerDorothy E Vatner
Apr 30, 2011·Journal of the American College of Cardiology·Tong TangN Chin Lai
Jan 26, 2018·Journal of Cardiovascular Development and Disease·Tanya A Baldwin, Carmen W Dessauer
Jan 4, 2019·Cardiovascular Research·Nathalie MougenotLarissa Lipskaia
Jul 13, 2016·The Journal of Pharmacology and Experimental Therapeutics·Claudio A BravoStephen F Vatner
Aug 28, 2018·Frontiers in Pharmacology·Claudio de LuciaWalter J Koch
May 8, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gabriel Komla AdzikaHong Sun
Aug 1, 2018·JACC. Basic to Translational Science·Dimosthenis GiamouridisH Kirk Hammond
Jan 24, 2021·Cardiovascular Research·Yuening LiuZhaokang Cheng
Mar 7, 2021·Cells·Giulietta Di BenedettoKonstantinos Lefkimmiatis
May 1, 2021·Cells·Anne-Sophie Colombe, Guillaume Pidoux

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.