Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan

Circulation Research
Arantxa GonzalezAnnarosa Leri

Abstract

Heart failure is the leading cause of death in the elderly, but whether this is the result of a primary aging myopathy dictated by depletion of the cardiac progenitor cell (CPC) pool is unknown. Similarly, whether current lifespan reflects the ineluctable genetic clock or heart failure interferes with the genetically determined fate of the organ and organism is an important question. We have identified that chronological age leads to telomeric shortening in CPCs, which by necessity generate a differentiated progeny that rapidly acquires the senescent phenotype conditioning organ aging. CPC aging is mediated by attenuation of the insulin-like growth factor-1/insulin-like growth factor-1 receptor and hepatocyte growth factor/c-Met systems, which do not counteract any longer the CPC renin-angiotensin system, resulting in cellular senescence, growth arrest, and apoptosis. However, pulse-chase 5-bromodeoxyuridine-labeling assay revealed that the senescent heart contains functionally competent CPCs that have the properties of stem cells. This subset of telomerase-competent CPCs have long telomeres and, following activation, migrate to the regions of damage, where they generate a population of young cardiomyocytes, reversing partly th...Continue Reading

References

Dec 10, 1992·The New England Journal of Medicine·J Y Wei
Jun 5, 2002·Trends in Genetics : TIG·Christy S CarterWilliam E Sonntag
Dec 17, 2002·Nature·Martin HolzenbergerYves Le Bouc
Mar 1, 2003·Science·Marc TatarAdam Antebi
Jul 17, 2003·The Journal of Clinical Investigation·Orit KolletTsvee Lapidot
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Dec 13, 2003·Science·Tudorita TumbarElaine Fuchs
Jan 28, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Joëlle Dupont, Martin Holzenberger
Feb 12, 2004·Genes & Development·Bernhard MaierHeidi Scrable
Jul 13, 2004·Annals of the New York Academy of Sciences·Shosuke Kawanishi, Shinji Oikawa
Nov 25, 2004·Hematology·Grover C BagbyCharles A Schiffer
Jun 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekPiero Anversa
Jun 10, 2005·Nature·Warren C Sanderson, Sergei Scherbov
Jun 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Axel LinkePiero Anversa
Jun 16, 2005·American Journal of Physiology. Renal Physiology·Shuo YangLeonard G Meggs
Sep 27, 2005·Physiological Reviews·Annarosa LeriPiero Anversa
May 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael E DavisRichard T Lee
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konrad UrbanekAnnarosa Leri
Sep 8, 2006·Nature·Christian M Beausejour, Judith Campisi
Apr 26, 2007·Nature Reviews. Cancer·Thomas ForceRichard A Van Etten

❮ Previous
Next ❯

Citations

Feb 17, 2009·Biogerontology·Jan O Nehlin, Torben Barington
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Toru HosodaAnnarosa Leri
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rosemeire M Kanashiro-TakeuchiJoshua M Hare
Jan 11, 2012·Antioxidants & Redox Signaling·Dao-Fu DaiPeter S Rabinovitch
Jul 24, 2010·Stem Cells and Development·Andrea MeinhardtGiuseppe Vassalli
Mar 5, 2010·British Medical Bulletin·Joon Lee, Cesare M Terracciano
Dec 3, 2008·Cardiovascular Research·Liza S M WongPim van der Harst
Jun 26, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan UngvariAnna Csiszar
Apr 10, 2013·Cardiology in Review·Matthew SchoenfeldPiero Anversa
Feb 27, 2009·The Journal of Cardiovascular Nursing·John M Collins, Brenda Russell
Jun 10, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Marcus CarlssonMaythem Saeed
Jun 7, 2008·Circulation Research·Stefanie Dimmeler, Annarosa Leri
Sep 12, 2009·Circulation Research·João Ferreira-MartinsMarcello Rota
Jun 5, 2010·Circulation Research·Jan KajsturaPiero Anversa
Feb 26, 2011·Circulation Research·Kimberlee M FischerMark A Sussman
Mar 19, 2011·Circulation Research·Polina GoichbergAnnarosa Leri
Apr 14, 2012·Circulation Research·Luigi FontanaValter D Longo
Sep 17, 2011·Circulation Research·Lauren Gerard KochUlrik Wisløff
Jan 26, 2012·Circulation Research·João Ferreira-MartinsMarcello Rota
Jan 3, 2013·The Journal of Clinical Investigation·Piero AnversaAnnarosa Leri
Nov 19, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Toru HosodaPiero Anversa
Nov 19, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Tohru Minamino
Mar 20, 2012·PloS One·Lei YeJianyi Jay Zhang
Sep 30, 2010·The Tohoku Journal of Experimental Medicine·Jun ZhangTen Wang
Aug 21, 2013·Cellular and Molecular Life Sciences : CMLS·Domiziana CostamagnaMaurilio Sampaolesi
Mar 7, 2014·Antioxidants & Redox Signaling·Polina GoichbergAnnarosa Leri
Mar 4, 2010·Stem Cell Reviews and Reports·Runqian SuiQi Tan
Jul 28, 2010·American Journal of Epidemiology·Tatiana KuznetsovaNilesh J Samani
Sep 25, 2012·Heart Failure Reviews·Alexander T Akhmedov, José Marín-García
Feb 16, 2013·Basic Research in Cardiology·Elena PiegariFrancesco Rossi
Aug 6, 2013·Mayo Clinic Proceedings·Piero Anversa, Annarosa Leri
Aug 8, 2012·Trends in Cardiovascular Medicine·Lauren Gerard KochUlrik Wisløff
Jul 17, 2012·Archives of Gerontology and Geriatrics·Qinghong Li, Steven S Hannah
Nov 24, 2011·Heart Failure Clinics·James B Strait, Edward G Lakatta
May 3, 2011·Trends in Endocrinology and Metabolism : TEM·Hippokratis KiarisAndrew V Schally

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Konrad UrbanekPiero Anversa
Proceedings of the National Academy of Sciences of the United States of America
Toru HosodaAnnarosa Leri
Proceedings of the National Academy of Sciences of the United States of America
Claudia BearziPiero Anversa
© 2021 Meta ULC. All rights reserved