Oct 1, 1989

Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex

The Journal of Experimental Medicine
T MatsuyamaC Morimoto

Abstract

In this study, fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system. The cell-adhesive domain plus additional regions of the fibronectin molecule are involved in this synergy. Anti4B4(CDw29) antibody blocked the activation of CD4 cells in this system. Furthermore, it is the VLA-5 protein within the set of molecules recognized by anti-4B4 that serves as a fibronectin receptor on the CD4 lymphocytes. The VLA-5 fibronectin receptor was mainly expressed on CD4+ CD45R-CDw29+ cells and may in part contribute to the unique function of these cells.

Mentioned in this Paper

Monoclonal Antibodies
T6 Antigens
Extracellular Matrix
Lymphocyte Activation
FN1
CD4 Positive T Lymphocytes
Fibronectins
T-Cell Receptor
CD3 Antigens
PTPRC gene

About this Paper

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