PMID: 8610140Apr 2, 1996Paper

Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules

Proceedings of the National Academy of Sciences of the United States of America
Z Razi-WolfH Reiser

Abstract

Interleukin 2 (IL-2)-deficient (IL-2-/-) mice develop hemolytic anemia and chronic inflammatory bowel disease. Importantly, the induction of disease in IL-2-deficient mice is critically dependent on CD4+ T cells. We have studied the requirements of T cells from IL-2-deficient mice for costimulation with B7 antigens. Stable B7-1 or B7-2 chinese hamster ovary (CHO) cell transfectants could synergize with anti-CD3 monoclonal antibody (mAb) to induce the proliferation of CD4+ T cells from IL-2-/- mutant mice. Further mechanistic studies established that B7-induced activation resulted in surface expression of the alpha chain of the IL-2 receptor. B7-induced proliferation occurred independently of IL-4 and was largely independent of the common gamma chain of the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors. Finally, anti-B7-2 but not anti-B7-1 mAb was able to inhibit the activation of IL-2-/- T cells induced by anti-CD3 mAb in the presence of syngeneic antigen-presenting cells. The results of our experiments indicate that IL-2-/- CD4+ T cells remain responsive to B7 stimulation and raise the possibility that B7 antagonists have a role in the prevention/treatment of inflammatory bowel disease.

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Citations

Jan 5, 2005·Digestive Diseases and Sciences·Marco ScarpaDavide Francesco D'Amico
Apr 17, 2003·Life Sciences·Umberto DianzaniUgo Ramenghi
Sep 3, 2004·Nature Reviews. Immunology·Thomas R Malek, Allison L Bayer
Oct 31, 1996·The New England Journal of Medicine·H Reiser, M J Stadecker
Feb 12, 2002·Inflammatory Bowel Diseases·David L BooneAveril Ma
Feb 28, 2002·Annual Review of Immunology·Warren StroberRichard S Blumberg
Mar 20, 2001·The Journal of Clinical Investigation·M M KosiewiczF Cominelli
Jun 18, 2002·Seminars in Oncology·Francine M Foss
Sep 16, 2003·Journal of Leukocyte Biology·Elisabet CantóSilvia Vidal
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T R MalekE K Codias
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E K KapsogeorgouM N Manoussakis
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara ColombettiAnna Mondino
Sep 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min ShiLeslie J Berg
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Phillip Wong, Eric G Pamer
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanne L AttemaM Frances Shannon

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