Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals

Experimental Neurology
Chaonan DingPing-An Li

Abstract

Mitochondria play a critical role in the pathogenesis of cerebral ischemia. Acute hyperglycemia has been shown to activate the mitochondria-initiated cell death pathway after an intermediate period of ischemia. The objective of the present study was to determine if diabetic hyperglycemia induced by streptozotocin activates the cell death pathway after a brief period of global ischemia. Five minutes of global ischemia was induced in nondiabetic and diabetic rats. Brain samples were collected after 30 min, 6 h, 1, 3, and 7 days of recirculation as well as from sham-operated controls. Histopathological examination in the hippocampal CA1, CA3, hilus, and dentate gyrus regions, as well as in the cortical and thalamic areas, showed that neuronal death in diabetic animals increased compared to nondiabetic ischemic controls. Neuronal damage maturation occurred after 7 days of recovery in nondiabetic rats, while it was shortened to 3 days of recovery in diabetic animals. Western blot analyses revealed that release of cytochrome c markedly increased after 1 and 3 days of reperfusion in diabetic rats. Caspase-3 activation was evident in the nuclear fraction of the cortex of diabetic rats after 3 days recovery and it was preceded by activa...Continue Reading

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Citations

Mar 8, 2005·Journal of Neuroimmunology·Chaonan DingPing-An Li
May 1, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Angelo CarneiroJosé Paulo Andrade
Oct 29, 2013·International Journal of Biological Sciences·Li JingP Andy Li
Jan 31, 2006·Neurologic Clinics·Izumi Harukuni, Anish Bhardwaj
Nov 26, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Vickie H Y WongAlgis J Vingrys
Dec 8, 2010·Brain Research·Hitoshi NukadaSoroku Yagihashi
Feb 27, 2013·Revista brasileira de anestesiologia·Rogean Rodrigues NunesSara Lúcia Cavalcante
Feb 26, 2014·Brazilian Journal of Anesthesiology·Rogean Rodrigues NunesSara Lúcia Cavalcante
Oct 20, 2017·Laboratory animal research·Dong-Ju ParkPhil-Ok Koh
Apr 5, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Sanjoy GhoshBrian Rodrigues

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