Activation of cerebellar lobules VI-VII during motor imagery but not during motor activation in unilateral cerebellar hypoplasia

Cerebellum & Ataxias
C Habas, Mario Manto

Abstract

We report the case of a 25 year-old patient who underwent morphological and functional brain magnetic resonance imaging (fMRI) to investigate a left neocerebellar hypoplasia discovered incidentally. We compared brain activation during overt and covert finger movements, and haptic discrimination. The contralateral cerebellar hemisphere compensated for mental imagery of hand movements and haptic discrimination, but not for motor execution. Moreover, the resting-state functional connectivity did not show compensatory functional coherence between the right cerebellum and cerebral areas connected with the hypoplastic cerebellum. Our case illustrates for the first time that cerebellar compensatory recruitment is an active, specific process related to task complexity and under the control of executive networks.

References

Aug 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stéphane LehéricyJulien Doyon
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christophe HabasMichael D Greicius
Feb 12, 2013·Journal of Motor Behavior·Arnaud SaimpontPhilip L Jackson

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Citations

May 4, 2017·Neuro-degenerative Diseases·Margot Samson, Daniel O Claassen

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Methods Mentioned

BETA
SMA

Software Mentioned

Independent Component Analysis ( MELODIC
Volume One
FMRIB FSL

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