PMID: 9175600May 2, 1997Paper

Activation of chemosensitive neurons in the ventrolateral medulla by capsaicin in cats

Neuroscience Letters
H SellerJ Zanzinger

Abstract

We examined effects of centrally administered capsaicin on sympathetic nerve activity (SNA), blood pressure (BP) and heart rate (HR) in chloralose anesthetized cats (n = 18). Upon perfusion of the lower brain stem via the left vertebral artery, capsaicin (0.1-1.0 microM) caused dose-dependent increases in preganglionic SNA (recorded from the white ramus T3) that were associated with rises in BP and HR. These responses resembled closely those obtained during perfusions with CO2-enriched (40-80%) saline. Coadministration of capsaicin and CO2 resulted in additively increased responses. The effects of capsaicin, but not those of CO2, were significantly counteracted by the capsaicin antagonist capsazepine and ruthenium red. These results suggest that a specific central chemosensitivity activated by vanilloid receptor agonists may modulate hypercapnic and/or acidic sympathoexcitatory stimuli in vivo.

References

Apr 1, 1990·Respiration Physiology·T ChonanN S Cherniack
Aug 1, 1990·Pflügers Archiv : European journal of physiology·H SellerJ Czachurski
Mar 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·G Jancsó, G Such
Sep 1, 1995·Pflügers Archiv : European journal of physiology·S A KönigH Seller
Dec 1, 1994·Trends in Neurosciences·S Bevan, P Geppetti
Dec 5, 1994·Neuroscience Letters·S V KoulchitskyV A Kulchitsky

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Citations

Apr 9, 2002·European Journal of Pharmacology·Enza PalazzoSabatino Maione
Sep 25, 1999·Japanese Journal of Pharmacology·T Sasamura, Y Kuraishi
May 15, 2008·International Archives of Occupational and Environmental Health·L AnderssonM Bende

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