Abstract
It has been suggested that blood coagulation be activated and fibrinolytic activity be impaired in patients with coronary artery disease (CAD). With regard to the activation of coagulation and fibrinolysis occurring during exercise in healthy individuals, we examined the hypothesis that rehabilitative exercise in patients with CAD might give rise to an exaggerated activation of coagulation. In 12 patients with angiographically documented CAD without myocardial infarction within the preceding 6 months (male, age 55+/-9 years [SD]) and in 12 healthy controls (male, 52+/-7 years), molecular markers of thrombin, fibrin, and plasmin formation were determined before and after a rehabilitative group exercise session lasting 1 hour. Resting levels of prothrombin fragment 1+2 were lower in patients with CAD (0.67+/-0.2 [SE] vs 1.04+/-0.2 nmol/L, p <0.001) and remained unchanged after exercise, whereas a significant increase was noted in controls (p <0.01). After exercise, plasma levels of thrombin-antithrombin III complexes and of fibrinopeptide A increased significantly in both groups, although there were more pronounced changes in controls. Exercise resulted in a marked generation of plasmin as indicated by plasmin-alpha2-antiplasmin ...Continue Reading
References
Jul 1, 1992·Circulation·G SchulerM Grunze
Feb 1, 1990·Journal of Clinical Pharmacology·A C Teger-NilssonB Ablad
Dec 1, 1987·The Journal of Clinical Investigation·K A BauerR D Rosenberg
Jan 1, 1987·Circulation·P ThérouxJ De Lara
Oct 1, 1988·Medicine and Science in Sports and Exercise·R E Bourey, S A Santoro
Nov 16, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·G UrdénB Wiman
Oct 15, 1995·The American Journal of Cardiology·J NiebauerG Schuler
Dec 1, 1994·Circulation·T HerrenP W Straub
Jul 1, 1994·Circulation·P A MerliniR D Rosenberg
Dec 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R LassilaV Manninen
Oct 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M CortellaroG Specchia
Jan 1, 1993·European Heart Journal
Jun 1, 1993·Stroke; a Journal of Cerebral Circulation·H TohgiK Tamura
Mar 1, 1996·Sports Medicine·R Eston, D Connolly
Citations
Nov 30, 1999·Lancet·P Bärtsch
Nov 12, 2013·Journal of Thrombosis and Thrombolysis·Kathleen E Brummel-ZiedinsThomas Orfeo
Mar 19, 2005·Heart·K W LeeUNKNOWN BRUM Investigators
Sep 23, 2010·European Journal of Applied Physiology·Kathleen Menzel, Thomas Hilberg
Aug 15, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P BurnsA W Bradbury
Jan 25, 2017·Thrombosis Journal·Joanna CwikielArnljot Flaa
Sep 10, 2003·Sports Medicine·Christopher J WomackAdam M Coughlin
Feb 28, 2004·Sports Medicine·Mahmoud S El-SayedSajad Ahmadizad
Mar 30, 2006·Journal of Cardiopulmonary Rehabilitation·Jane E Freedman