Activation of coagulation and fibrinolysis after rehabilitative exercise in patients with coronary artery disease

The American Journal of Cardiology
C WeissP Bärtsch

Abstract

It has been suggested that blood coagulation be activated and fibrinolytic activity be impaired in patients with coronary artery disease (CAD). With regard to the activation of coagulation and fibrinolysis occurring during exercise in healthy individuals, we examined the hypothesis that rehabilitative exercise in patients with CAD might give rise to an exaggerated activation of coagulation. In 12 patients with angiographically documented CAD without myocardial infarction within the preceding 6 months (male, age 55+/-9 years [SD]) and in 12 healthy controls (male, 52+/-7 years), molecular markers of thrombin, fibrin, and plasmin formation were determined before and after a rehabilitative group exercise session lasting 1 hour. Resting levels of prothrombin fragment 1+2 were lower in patients with CAD (0.67+/-0.2 [SE] vs 1.04+/-0.2 nmol/L, p <0.001) and remained unchanged after exercise, whereas a significant increase was noted in controls (p <0.01). After exercise, plasma levels of thrombin-antithrombin III complexes and of fibrinopeptide A increased significantly in both groups, although there were more pronounced changes in controls. Exercise resulted in a marked generation of plasmin as indicated by plasmin-alpha2-antiplasmin ...Continue Reading

References

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Citations

Nov 12, 2013·Journal of Thrombosis and Thrombolysis·Kathleen E Brummel-ZiedinsThomas Orfeo
Aug 15, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P BurnsA W Bradbury
Jan 25, 2017·Thrombosis Journal·Joanna CwikielArnljot Flaa
Feb 28, 2004·Sports Medicine·Mahmoud S El-SayedSajad Ahmadizad
Mar 30, 2006·Journal of Cardiopulmonary Rehabilitation·Jane E Freedman

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