PMID: 15238823Jul 9, 2004Paper

Activation of coagulation system in dilated cardiomyopathy: comparison of patients with and without left ventricular thrombus

Coronary Artery Disease
Ali Riza ErbayErtan Yetkin

Abstract

We aimed to investigate plasma levels of molecular markers for platelet activity, thrombin activation and fibrinolytic status in patients with dilated cardiomyopathy (DCM) with and without left ventricular (LV) thrombus and to compare these markers between patients with DCM and control participants. The study population comprised 60 patients with DCM who met the inclusion criteria. Patients were divided into two groups: 22 patients with LV thrombus and 38 patients without LV thrombus. The age-matched control group consisted of 23 healthy participants (18 men and five women with a mean age of 49). Patients with DCM and healthy participants were compared with respect to platelet activity, thrombin activation and fibrinolytic status. These comparisons were also performed in patients with DCM with and without LV thrombus. Platelet factor 4 (28.2+/-4.4 ng/ml compared with 20+/-3.1 ng/ml, P<0.01) and beta-thromboglobulin (40+/-2 ng/ml compared with 17+/-3 ng/ml) levels, reflecting platelet activity, were significantly higher in patients with DCM than in control participants. Fibrinopeptide A (6.94+/-0.69 ng/ml compared with 1.96+/-0.1 ng/ml, P<0.001) and thrombin-antithrombin III complex (5.26+/-2.60 ng/ml compared with 3.17+/-1.23 n...Continue Reading

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Citations

May 10, 2008·Journal of Veterinary Internal Medicine·T StokolA L Gelzer
Nov 2, 2012·Journal of the American Veterinary Medical Association·Andrea ZoiaMarco Caldin
Oct 6, 2005·Journal of Cellular and Molecular Medicine·Karni S MoshalSuresh C Tyagi
Feb 24, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·N A WindeløvL S Rasmussen
Apr 26, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Nasir SivriJohannes Waltenberger
Jun 13, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Ertan YetkinMahmut Ozten

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