Activation of cortical and inhibited differentiation of medullary epithelial cells in the thymus of lymphotoxin-beta receptor-deficient mice: an ultrastructural study

Journal of Anatomy
N M MilićevićJürgen Westermann

Abstract

The reciprocal influences of thymic lymphocyte and nonlymphocyte populations, i.e. thymic cross-talk, are necessary for the proper maturation of thymocytes and the development/maintenance of thymic stromal microenvironments. Although the molecular influences exerted by thymic stromal cells on maturing thymocytes have been extensively studied, the identity of signalling molecules used by thymocytes to influence the thymic stromal cells is still largely unknown. Our study provides the first ultrastructural evidence that the functional lymphotoxin-beta receptor (LTbetaR) signalling pathway is engaged in the cross-talk between thymocytes and the thymic stromal cell population. We show that LTbetaR signalling is of the utmost significance for the preservation of the subcellular integrity of all thymic epithelial cells. In the absence of LTbetaR there is (1) hypertrophy and activation of cortical thymic epithelial cells, (2) the complete loss of fully differentiated medullary thymic epithelial cells, and (3) the inhibited differentiation of remaining medullary thymic epithelial cells with the appearance of prominent intercellular cysts in the thymic medulla.

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Citations

Jan 17, 2009·Histochemistry and Cell Biology·Novica M MilićevićJürgen Westermann
May 26, 2011·Histochemistry and Cell Biology·Novica M MilićevićJürgen Westermann
Mar 10, 2011·Age·Mohammad Nizam UddinKen-ichi Isobe
Mar 2, 2010·Cellular & Molecular Immunology·Mingzhao Zhu, Yangxin Fu
Sep 2, 2009·Immunology and Cell Biology·Zivana MilićevićJürgen Westermann
Jan 29, 2013·Progress in Histochemistry and Cytochemistry·Novica M Milićević, Živana Milićević
Jul 11, 2008·Immunological Reviews·Jeffrey L Browning
Sep 14, 2016·Cytokine·Ekaterina P KorolevaAlexei V Tumanov
Apr 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian H YokleyPhillip E Posch

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