Activation of corticotropin releasing factor-containing neurons in the rat central amygdala and bed nucleus of the stria terminalis following exposure to two different anxiogenic stressors

Behavioural Brain Research
R K ButlerMarlene A Wilson

Abstract

Rats exposed to the odor of a predator or to the elevated plus maze (EPM) express unique unconditioned fear behaviors. The extended amygdala has previously been demonstrated to mediate the response to both predator odor and the EPM. We seek to determine if divergent amygdalar microcircuits are associated with the different behavioral responses. The current experiments compared activation of corticotropin-releasing factor (CRF)-containing neuronal populations in the central amygdala and bed nucleus of the stria terminalis (BNST) of rats exposed to either the EPM (5 min) versus home cage controls, or predator (ferret) odor versus butyric acid, or no odor (30 min). Sections of the brains were prepared for dual-labeled immunohistochemistry and counts of c-Fos co-localized with CRF were made in the centrolateral and centromedial amygdala (CLA and CMA) as well as the dorsolateral (dl), dorsomedial (dm), and ventral (v) BNST. Ferret odor-exposed rats displayed an increase in duration and a decrease in latency of defensive burying versus control rats. Exposure to both predator stress and EPM induced neuronal activation in the BNST, but not the central amygdala, and similar levels of neuronal activation were seen in both the high and lo...Continue Reading

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Citations

Aug 12, 2016·Experimental Neurology·Judith K Daniels, Eric Vermetten
Apr 27, 2019·Frontiers in Behavioral Neuroscience·Olivia W Miles, Stephen Maren
Aug 18, 2017·Learning & Memory·Travis D Goode, Stephen Maren
Feb 3, 2021·Animals : an Open Access Journal From MDPI·Mirosław KarpińskiMagdalena Krauze
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoshinori MasuoKazuo Koike
Jun 25, 2021·The British Journal of Nutrition·Mina Sadat Izadi, Maryam Radahmadi

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