Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Antony D AbrahamK Matthew Lattal

Abstract

Dopamine is critical for many processes that drive learning and memory, including motivation, prediction error, incentive salience, memory consolidation, and response output. Theories of dopamine's function in these processes have, for the most part, been developed from behavioral approaches that examine learning mechanisms in appetitive tasks. A parallel and growing literature indicates that dopamine signaling is involved in consolidation of memories into stable representations in aversive tasks such as fear conditioning. Relatively little is known about how dopamine may modulate memories that form during extinction, when organisms learn that the relation between previously associated events is severed. We investigated whether fear and reward extinction share common mechanisms that could be enhanced with dopamine D1/5 receptor activation. Pharmacological activation of dopamine D1/5 receptors (with SKF 81297) enhanced extinction of both cued and contextual fear. These effects also occurred in the extinction of cocaine-induced conditioned place preference, suggesting that the observed effects on extinction were not specific to a particular type of procedure (aversive or appetitive). A cAMP/PKA biased D1 agonist (SKF 83959) did n...Continue Reading

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Citations

Jul 18, 2016·Neurobiology of Learning and Memory·Antony D AbrahamK Matthew Lattal
Aug 1, 2018·Journal of Cognitive Neuroscience·Vishnu P MurtyLila Davachi
Jan 19, 2019·Psychopharmacology·Emma N Cahill, Amy L Milton
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Jan 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Caitlin E BurgdorfAnjali M Rajadhyaksha
Sep 26, 2019·Nature Neuroscience·Ekaterina Likhtik, Joshua P Johansen
Mar 10, 2017·Frontiers in Behavioral Neuroscience·Isabel C ZbukvicJee Hyun Kim
Oct 5, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Courtney A BouchetBenjamin N Greenwood
May 10, 2018·Scientific Reports·Lizeth K PedrazaLucas de Oliveira Alvares
Jun 21, 2018·Frontiers in Behavioral Neuroscience·Natalie DittertMartin J Herrmann
Aug 18, 2020·Translational Psychiatry·Josh M CislerClinton D Kilts
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May 22, 2021·Behaviour Research and Therapy·Kevin M CrombieJosh M Cisler
Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margaux M KenwoodHelen Barbas

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