PMID: 9531562May 16, 1998Paper

Activation of distinct alpha5beta1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domains

The Journal of Cell Biology
Denise C HockingP J McKeown-Longo

Abstract

The interaction of cells with fibronectin generates a series of complex signaling events that serve to regulate several aspects of cell behavior, including growth, differentiation, adhesion, and motility. The formation of a fibronectin matrix is a dynamic, cell-mediated process that involves both ligation of the alpha5beta1 integrin with the Arg-Gly-Asp (RGD) sequence in fibronectin and binding of the amino terminus of fibronectin to cell surface receptors, termed "matrix assembly sites," which mediate the assembly of soluble fibronectin into insoluble fibrils. Our data demonstrate that the amino-terminal type I repeats of fibronectin bind to the alpha5beta1 integrin and support cell adhesion. Furthermore, the amino terminus of fibronectin modulates actin assembly, focal contact formation, tyrosine kinase activity, and cell migration. Amino-terminal fibronectin fragments and RGD peptides were able to cross-compete for binding to the alpha5beta1 integrin, suggesting that these two domains of fibronectin cannot bind to the alpha5beta1 integrin simultaneously. Cell adhesion to the amino-terminal domain of fibronectin was enhanced by cytochalasin D, suggesting that the ligand specificity of the alpha5beta1 integrin is regulated by ...Continue Reading

References

Apr 1, 1979·Hoppe-Seyler's Zeitschrift für physiologische Chemie·F Jilek, H Hörmann
Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·L H RomerC E Turner
Oct 1, 1992·Current Opinion in Cell Biology·D F MosherJ A McDonald
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D SchallerJ T Parsons
Jun 1, 1991·The Journal of Cell Biology·J E Schwarzbauer
Jan 1, 1987·Methods in Enzymology·R PytelaE Ruoslahti
Mar 1, 1987·The Journal of Cell Biology·P J McKeown-Longo, C A Etzler
Oct 1, 1987·The Journal of Cell Biology·J A Cooper
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T E PetersenS Magnusson
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M D Pierschbacher, E Ruoslahti
Jan 1, 1984·Annual Review of Medicine·D F Mosher
Dec 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L T FurchtJ M Foidart
May 1, 1995·Molecular and Cellular Biology·M D Schaller, J T Parsons
Jul 21, 1995·The Journal of Biological Chemistry·S L BellisC E Turner
May 26, 1995·The Journal of Biological Chemistry·P E HughesM H Ginsberg
Oct 1, 1994·Current Opinion in Cell Biology·M D Schaller, J T Parsons
Mar 15, 1994·Biochemical and Biophysical Research Communications·N G McKayD A Power
Oct 1, 1995·Current Opinion in Cell Biology·A HuttenlocherA F Horwitz
Apr 1, 1996·The Journal of Cell Biology·D C HockingP J McKeown-Longo
Jul 12, 1996·The Journal of Biological Chemistry·W Puzon-McLaughlinY Takada
Jan 1, 1995·Annual Review of Cell and Developmental Biology·B M JockuschJ Winkler
Jan 1, 1995·Annual Review of Cell and Developmental Biology·M A SchwartzM H Ginsberg
Sep 1, 1996·The Journal of Cell Biology·A HuttenlocherA F Horwitz

❮ Previous
Next ❯

Citations

Oct 27, 2004·Archives of Dermatological Research·Sompid KintarakSimon A Whawell
Jun 22, 2006·Journal of Cancer Research and Clinical Oncology·Aparna MitraAmitava Chatterjee
Sep 17, 2002·Current Opinion in Cell Biology·Edna CukiermanKenneth M Yamada
Sep 29, 2011·The Journal of Biological Chemistry·Tomoo Ohashi, Harold P Erickson
Sep 16, 2006·Human Gene Therapy·Kirsten A Weigel-KelleyArun Srivastava
Oct 2, 2012·Tissue Engineering. Part a·Daniel C Roy, Denise C Hocking
May 26, 2010·Infection and Immunity·Tiffany M TsangEric S Krukonis
May 29, 2008·Molecular and Cellular Biology·Morvarid Mohseni, Athar H Chishti
Oct 10, 2007·Biochemistry. Biokhimii︠a︡·A A Terentiev, N T Moldogazieva
Aug 4, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·David F Meoli, R James White
Mar 14, 2012·Fibrogenesis & Tissue Repair·Francisco Caiado, Sérgio Dias
Apr 24, 2014·Advances in Wound Care·Carlos ZgheibKenneth W Liechty
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·D CraigV Vogel
Aug 10, 2010·Annual Review of Cell and Developmental Biology·Purva SinghJean E Schwarzbauer
Feb 3, 2005·The Journal of Cell Biology·Ying WeiHarold A Chapman
Feb 23, 2000·The Journal of Cell Biology·S S AkimovA M Belkin
Apr 21, 2010·Experimental Cell Research·Ian R EllisSeth L Schor
Apr 7, 2009·Trends in Cardiovascular Medicine·Guido KrenningMartin C Harmsen
Jul 8, 2003·The Journal of Pathology·G Gabbiani
Oct 13, 2005·Proteomics·Cristina BanfiElena Tremoli
May 13, 2006·Journal of Thrombosis and Haemostasis : JTH·J Cho, D F Mosher
Oct 13, 2016·Journal of Tissue Engineering and Regenerative Medicine·Nolan B SkopSteven W Levison
May 30, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ujjwala M WarawdekarNarendra G Mehta
Mar 29, 2006·Matrix Biology : Journal of the International Society for Matrix Biology·Bianca R Tomasini-JohanssonDeane F Mosher
Aug 2, 2001·Experimental Cell Research·Q ZhaoP Collodi
Aug 30, 2014·Matrix Biology : Journal of the International Society for Matrix Biology·Richard F Loeser
Jul 22, 1999·Experimental Cell Research·G Serini, G Gabbiani
Sep 20, 2011·Fibrogenesis & Tissue Repair·Wing S To, Kim S Midwood
Oct 26, 2007·Biochemical and Biophysical Research Communications·Gabriel MitchellFrançois Malouin
Nov 24, 1999·Mechanisms of Development·A Beauvais-JouneauL Larue
Jan 28, 2003·Biophysical Journal·Feiya LiVincent T Moy
Apr 22, 2009·Experimental Cell Research·Cornelia E CrookeGraham F Carpenter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.