Activation of dopamine D1 receptors enhances the temporal summation and excitability of rat retinal ganglion cells

Neuroscience
Peng CuiZhongfeng Wang

Abstract

Dopamine (DA), an important neurotransmitter and neuromodulator, plays important roles in neuronal physiological functions by activating G-protein-coupled DA D1 and/or D2 receptors. Previous studies have demonstrated that D1 receptors are functionally expressed in retinal neurons and glial cells, including ganglion cells. In this study, we explored the effects of D1 receptor activation on retinal ganglion cell (RGC) temporal summation and excitability in rat retinal slices using electrophysiological techniques. Bath application of the selective D1 receptor agonist SKF81297 increased the ratio of excitatory postsynaptic potentials (EPSPs) (EPSP5/EPSP1) within an EPSP train evoked by a train stimulation (five current pulses at 40Hz), which was blocked by co-application of SCH23390, a specific D1 receptor antagonist. Ba2+, an inwardly rectifying K+ channel (Kir) blocker, significantly suppressed the SKF81297-induced effect, whereas ZD7288, a specific hyperpolarization-activated cation current (Ih) blocker, showed a moderate inhibitory effect. The cAMP/protein kinase A (PKA) signaling pathway, but not phosphoinositide-specific phospholipase C (PI-PLC), mediated the SKF81297-induced modulation of EPSP temporal summation. Further exp...Continue Reading

Citations

Oct 14, 2019·Neuroscience Bulletin·Ning YinZhongfeng Wang
Sep 7, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qian LiJihong Wu
Mar 20, 2019·Neuroscience Bulletin·Ling-Zhu LiZhongfeng Wang

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