Activation of dopamine D4 receptors within the anterior cingulate cortex enhances the erroneous expectation of reward on a rat slot machine task

Neuropharmacology
Paul J CockerCatharine A Winstanley

Abstract

Using a rodent slot machine task (rSMT), we have previously shown that rats, like humans, are susceptible to the reinforcing effects of winning signals presented within a compound stimulus array, even when the pattern generated predicts a negative rather than a positive outcome such as during a "near-miss". The dopamine D4 receptor critically mediates the erroneous reward expectancy generated on such trials. D4 receptors are particularly enriched within frontal and limbic areas activated during slot machine play, such as the anterior cingulate cortex (ACC). We therefore selectively inactivated the ACC to confirm involvement of this region in rSMT performance, and subsequently examined the specific contribution of local D4 receptors. ACC inactivations generally impaired animals' ability to optimally differentiate winning from losing outcomes. Local administration of the D4 agonist PD168077 had a qualitatively similar effect, but increased reward expectancy was only evident on archetypal "near-miss" trials i.e. when the first two of three stimuli in the array were concordant with a rewarding outcome, and only the last stimulus critically signalled a non-win. These data indicate that the ACC is critically involved in parsing the a...Continue Reading

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Citations

Dec 19, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher J BurkePhilippe N Tobler
Jul 28, 2019·Nature Reviews. Disease Primers·Marc N PotenzaSarah W Yip
Aug 22, 2017·Psychopharmacology·Patricia Di CianoBernard Le Foll
May 10, 2017·Annals of the New York Academy of Sciences·Katherine M NautiyalCarlos Blanco
Jan 11, 2021·European Journal of Medicinal Chemistry·Gianfabio GiorgioniAlessandro Piergentili

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