Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex.

Cerebral Cortex
Dongman ChaoYing Xia

Abstract

We have recently found that in the mouse cortex, activation of delta-opioid receptor (DOR) attenuates the disruption of K(+) homeostasis induced by hypoxia or oxygen-glucose deprivation. This novel observation suggests that DOR may protect neurons from hypoxic/ischemic insults via the regulation of K(+) homeostasis because the disruption of K(+) homeostasis plays a critical role in neuronal injury under hypoxic/ischemic stress. The present study was performed to explore the ionic mechanism underlying the DOR-induced neuroprotection. Because anoxia causes Na(+) influx and thus stimulates K(+) leakage, we investigated whether DOR protects the cortex from anoxic K(+) derangement by targeting the Na(+)-based K(+) leakage. By using K(+)-sensitive microelectrodes in mouse cortical slices, we showed that 1) lowering Na(+) concentration and substituting with impermeable N-methyl-D-glucamine caused a concentration-dependent attenuation of anoxic K(+) derangement; 2) lowering Na(+) concentration by substituting with permeable Li(+) tended to potentiate the anoxic K(+) derangement; and 3) the DOR-induced protection against the anoxic K(+) responses was largely abolished by low-Na(+) perfusion irrespective of the substituted cation. We con...Continue Reading

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Citations

Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Xuezhi KangYing Xia
Feb 4, 2009·Cellular and Molecular Life Sciences : CMLS·D ChaoY Xia
Aug 2, 2011·Chemical Reviews·Yulia V ShulgaRichard M Epand
Aug 28, 2013·International Journal of Molecular Sciences·Meaghan StaplesCesar V Borlongan
Jun 15, 2013·Pharmacology & Therapeutics·Paul Chu Sin Chung, Brigitte L Kieffer
May 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Dongman ChaoYing Xia
Sep 28, 2012·Cellular and Molecular Life Sciences : CMLS·Xiaozhou HeYing Xia
Dec 29, 2009·Progress in Neurobiology·Dongman Chao, Ying Xia
Oct 2, 2009·Peptides·Richard J Bodnar
Jan 25, 2014·CNS Neuroscience & Therapeutics·Albert J FenoyYing Xia
Jun 12, 2010·Annals of the New York Academy of Sciences·Stephen M Johnson, Sara M F Turner
Jul 24, 2014·British Journal of Pharmacology·Jianfeng LiangYing Xia
Jan 11, 2014·Progress in Neurobiology·Fan ChenXunming Ji
Apr 10, 2020·Frontiers in Immunology·Yi-Meng ChenYing Xia

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