PMID: 1176209Oct 15, 1975Paper

Activation of "eclipsed" lymphoid cells from advanced tumor-bearing mice through adoptive transfer to sublethally irradiated syngeneic hosts

International Journal of Cancer. Journal International Du Cancer
J K YounG Barski

Abstract

Immunologically inactive or "eclipsed" lymphoid cells from advanced tumor-bearing mice were investigated following their adoptive transfer to irradiated syngeneic hosts. Experiments were performed with two syngeneic tumor-host system: the T5-BALB/c tumor line chronically infected with a low-leukemogenic Rauscher virus variant and the TM1-C3H tumor line developed from a spontaneous C3H/He mouse mammary tumor. In confirmation of our previous data, peritoneal cells (PC) from advanced tumor-bearing mice (EPC) appeared to have lost any capacity to inhibit specifically the growth of corresponding tumor target cells in vitro colony inhibition (CI) tests, whereas PC from immunized mice (IPC) were perfectly active. When these EPC were adoptively transferred by intraperitoneal inoculation into sublethally irradiated (450 R) syngeneic mice in association with respective tumor extracts (TE), the PC from such recipient mice, taken 5 to 13 days later, were nearly as active in in vitro CI tests as were PC from parallel IPC-recipient mice. For this recovery of specific immunological activity following the adoptive transfer of EPC the adjunction of the TE and irradiation of the recipient animals seem important and may be necessary. On the other...Continue Reading

References

Jan 15, 1975·International Journal of Cancer. Journal International Du Cancer·S B HowellL W Law
Jul 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·C J Bellone, M Pollard
Mar 15, 1971·International Journal of Cancer. Journal International Du Cancer·V DiehlL Ahström
Feb 15, 1974·International Journal of Cancer. Journal International Du Cancer·M S Paranjpe, C W Boone
Apr 1, 1973·Journal of the National Cancer Institute·J K YounG Barski
May 15, 1974·International Journal of Cancer. Journal International Du Cancer·D Le FrançoisG Barski
Nov 1, 1972·The Journal of Experimental Medicine·M Ortiz de Landazuri, R B Herberman
Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H O SjögrenK E Hellström

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Citations

Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·R C HarmonY Mullen
Feb 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J K YounG Barski
Apr 15, 1980·International Journal of Cancer. Journal International Du Cancer·W C WangA H Sehon

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