PMID: 2501514Aug 1, 1989Paper

Activation of endogenous c-fos proto-oncogene expression by human T-cell leukemia virus type I-encoded p40tax protein in the human T-cell line, Jurkat

Journal of Virology
K NagataK Sugamura

Abstract

We examined the ability of the trans-acting factor p40tax of human T-cell leukemia virus type I (HTLV-I), which is thought to be a crucial molecule in T-cell transformation by HTLV-I, to activate expression of a set of endogenous cellular genes related to T-cell proliferation. For this purpose we established a subclone (JPX-9) of Jurkat cells that was stably transfected with an expression plasmid containing the p40tax gene, whose expression is definitely dependent on heavy-metal ions. Expression of the interleukin-2 receptor alpha chain in JPX-9 cells was induced in response to the induction of p40tax expression, as has been demonstrated by others in transient transfection experiments with Jurkat cells. In addition, we found that significant enhancement of expression of the nuclear proto-oncogene c-fos was closely associated with expression of p40tax. Continous enhancement in the level of c-fos mRNA was observed in the presence of p40tax. In contrast, mRNA levels of other nuclear proto-oncogenes (c-myc, c-myb, and c-jun) were not appreciably effected by the expression of p40tax. These results suggest that (i) in addition to the interleukin-2-interleukin-2 receptor system, cellular genes such as c-fos, which regulate normal T-ce...Continue Reading

References

Jan 1, 1985·Microbiology and Immunology·Y TanakaY Hinuma
Aug 18, 1988·Nature·W W LamphI M Verma
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M FujiiI M Verma
Jun 15, 1988·International Journal of Cancer. Journal International Du Cancer·H SabeJ Yodoi
Aug 1, 1985·The Journal of Clinical Investigation·T UchiyamaH Uchino
Nov 8, 1985·Science·W J LeonardW C Greene
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J C ReedR G Hoover
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H PaskalisG N Pavlakis
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M SiekevitzW C Greene
May 20, 1988·Science·F J RauscherB R Franza
May 1, 1973·International Journal of Cancer. Journal International Du Cancer·B M Reedman, G Klein
Aug 15, 1984·International Journal of Cancer. Journal International Du Cancer·K SugamuraY Hinuma
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·B J PoieszR C Gallo
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M SeikiM Yoshida
Jun 22, 1984·Science·D A Cantrell, K A Smith
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·F van StraatenI M Verma
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M PopovicR C Gallo
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma

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Citations

Jun 6, 1994·Annals of the New York Academy of Sciences·R VigneG Harkiss
Jan 2, 1993·International Journal of Cancer. Journal International Du Cancer·S ShioiriN Mueller
May 16, 1998·The Journal of Biological Chemistry·V N GladyshevD L Hatfield
Jun 25, 1999·AIDS Research and Human Retroviruses·M MoriuchiA S Fauci
Sep 13, 2005·Oncogene·William W Hall, Masahiro Fujii
Nov 21, 2007·International Reviews of Immunology·Benoit Barbeau, Jean-Michel Mesnard
Dec 6, 2012·Leukemia Research and Treatment·Nishat AliyaPooja Jain
Apr 19, 1996·The Journal of Biological Chemistry·O J SemmesK T Jeang
Jun 1, 1990·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·J LarkinD A Holt
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kunio HieshimaOsamu Yoshie
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Daisuke NagakuboOsamu Yoshie
Apr 22, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Inbal Azran-ShaishMordechai Aboud
Jun 25, 2014·The Journal of Clinical Investigation·Natsumi ArayaYoshihisa Yamano
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·V N GladyshevK T Jeang

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