PMID: 9429763Jan 16, 1998Paper

Activation of endothelial cell kinin receptors leads to intracellular calcium increases and filamin translocation: regulation by protein kinase C

Cellular Signalling
Q WangD Shepro

Abstract

Membrane-associated cytoskeletal proteins provide support for endothelial cell (EC) junctional cell adhesion molecules. Nonmuscle filamin is a dimeric actin cross-linking protein that interacts with F-actin and membrane glycoproteins. Both bradykinin and des-Arg9-bradykinin cause filamin redistribution from the plasma membrane to the cytosol of confluent EC. Kinin-induced filamin translocation parallels the dynamics of intracellular Ca2+ increases. Pretreatment with kinin receptor antagonists blocks the Ca2+ response as well as filamin translocation induced by kinins. Protein kinase C activation prior to kinin stimulation attenuates intracellular Ca2+ increases and filamin translocation. BAPTA, a cell-permeable Ca2+ chelator, attenuates bradykinin-induced intracellular Ca2+ increases and filamin translocation. This study demonstrates that bovine pulmonary artery ECs express both kinin B1 and B2 receptors, and that activation of either receptor leads to intracellular Ca2+ increases. This Ca2+ signalling, which is downregulated by protein kinase C activation, is essential for kinin-induced filamin translocation.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Apr 15, 1992·Biochemical and Biophysical Research Communications·J F HessR W Ransom
Nov 1, 1992·The American Journal of Physiology·W H WeintraubT E Machen
Jan 1, 1992·Journal of Physiology, Paris·P AndréJ C Stoclet
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C C GregorioE A Repasky
Nov 6, 1992·Science·E J Luna, A L Hitt
Dec 1, 1992·The Journal of Cell Biology·V M Fowler, E J Adam
Jan 1, 1991·Cell Motility and the Cytoskeleton·S DharmawardhaneJ Condeelis
Jan 1, 1992·Hypertension·A P Rocchini
Feb 1, 1992·Hypertension·J D Spence
Dec 1, 1989·Journal of Cellular Physiology·N M MorelD Shepro
Jun 1, 1985·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·R R Weihing
Apr 24, 1981·European Journal of Pharmacology·D C RegoliJ Lavigne
Jun 1, 1995·Immunopharmacology·F Marceau
Feb 1, 1994·Current Opinion in Cell Biology·A L Hitt, E J Luna
Feb 15, 1994·European Journal of Pharmacology·K A SchneckR W Ransom
Jan 1, 1996·Diabetes·R Busse, I Fleming
Feb 15, 1996·European Journal of Pharmacology·D PruneauP Bélichard
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MizutaF W Alt
Dec 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael W JacksonTom P Gordon

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Citations

Sep 5, 2006·Journal of Pineal Research·Eduardo K TamuraRegina P Markus
May 5, 2001·Biochimica Et Biophysica Acta·A van der Flier, A Sonnenberg
Mar 14, 2003·Obesity Research·Emilia PapakonstantinouRuth B S Harris
Oct 6, 1999·Obesity Research·N M Moussa, K J Claycombe
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S ShigematsuR J Korthuis
Apr 6, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·T BorbievJ G Garcia

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