Activation of endothelin A receptors contributes to impaired responsiveness of renal mechanosensory nerves in congestive heart failure.

Canadian Journal of Physiology and Pharmacology
U C KoppSusan Y Jones

Abstract

Increasing renal pelvic pressure results in PGE2-mediated release of substance P, leading to increases in afferent renal nerve activity (ARNA) and natriuresis, that is, a renorenal reflex response. The renorenal reflexes are impaired in congestive heart failure (CHF). Impairment of the renorenal reflexes may contribute to the increased renal sympathetic nerve activity and sodium retention in CHF. Endothelin (ET)-1 contributes to the pathological changes in cardiac and renal function in CHF. Therefore, we examined whether the ETA receptor antagonist BQ123 altered the responsiveness of renal mechanosensory nerves in CHF. The ARNA responses to increasing renal pelvic pressure were suppressed in CHF but not in sham-CHF rats. In CHF, increasing renal pelvic pressure by 7.5 mm Hg before and during renal pelvic perfusion with BQ123 increased ARNA 12% +/- 3% and 21% +/- 3% (p < 0.05 vs. vehicle). In isolated renal pelvises from CHF rats, PGE2 increased substance P release from 5 +/- 0 to 7 +/- 1 pg/min without BQ123 and from 4 +/- 1 to 9 +/- 1 pg/min with BQ123 in the bath (p < 0.01 vs. vehicle). BQ123 had no effect on the ARNA responses or substance P release in sham-CHF. In conclusion, activation of ETA receptors contributes to the i...Continue Reading

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Citations

Oct 21, 2015·Frontiers in Physiology·Lindsea C BoothSong T Yao
Aug 17, 2016·Autonomic Neuroscience : Basic & Clinical·Hong Zheng, Kaushik P Patel
Nov 21, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C Kopp
Jun 13, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sofia JönssonMichael Hultström
Jan 3, 2020·Kidney & Blood Pressure Research·Magali AraujoChristopher S Wilcox

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