Activation of EphB2 Forward Signaling Enhances Memory Consolidation

Cell Reports
Jessica M AlapinRaphael Lamprecht

Abstract

EphB2 is involved in enhancing synaptic transmission and gene expression. To explore the roles of EphB2 in memory formation and enhancement, we used a photoactivatable EphB2 (optoEphB2) to activate EphB2 forward signaling in pyramidal neurons in lateral amygdala (LA). Photoactivation of optoEphB2 during fear conditioning, but not minutes afterward, enhanced long-term, but not short-term, auditory fear conditioning. Photoactivation of optoEphB2 during fear conditioning led to activation of the cAMP/Ca2+ responsive element binding (CREB) protein. Application of light to a kinase-dead optoEphB2 in LA did not lead to enhancement of long-term fear conditioning memory or to activation of CREB. Long-term, but not short-term, auditory fear conditioning memory was impaired in mice lacking EphB2 forward signaling (EphB2lacZ/lacZ). Activation of optoEphB2 in LA of EphB2lacZ/lacZ mice enhanced long-term fear conditioning memory. The present findings show that the level of EphB2 forward signaling activity during learning determines the strength of long-term memory consolidation.

Citations

Apr 8, 2020·Frontiers in Synaptic Neuroscience·Amanda Q NguyenIryna M Ethell
Apr 30, 2019·Frontiers in Immunology·Stevan JeknićMarkus W Covert
Nov 11, 2020·Translational Psychiatry·Xin-Rong WuSuya Sun
Jan 21, 2021·International Journal of Molecular Sciences·Daniela LaricchiutaLaura Petrosini
Mar 3, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ahlem AssaliChristopher W Cowan
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Chunhai ChenLei Zhang
Jun 3, 2021·International Journal of Molecular Sciences·Markus M KramerGerald Radziwill

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