Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases

FEBS Letters
Juliane I BeierLars-Oliver Klotz

Abstract

Activation of ErbB receptor tyrosine kinases triggers multiple signaling pathways that regulate cellular proliferation and survival. We here demonstrate that ErbB2 is activated via the epidermal growth factor receptor (EGFR) upon exposure of cultured human keratinocytes to 2-methyl-1,4-naphthoquinone (menadione). Both ErbB2 and EGFR are shown to be regulated by protein tyrosine phosphatases that are inhibited by menadione, giving rise to the hypothesis that phosphatase inhibition by menadione may result in a net activation of EGFR and an enhanced ErbB2 phosphorylation. Isolated PTP-1B, a protein tyrosine phosphatase known to be associated with ErbB receptors, is demonstrated to be inhibited by menadione.

References

Jan 1, 1986·Biochemical Pharmacology·H Wefers, H Sies
Dec 1, 1984·Archives of Biochemistry and Biophysics·D Di MonteS Orrenius
Mar 24, 1995·Science·A Levitzki, A Gazit
Sep 3, 1999·The Journal of Biological Chemistry·S GrossF D Böhmer
Jul 25, 2000·Methods in Enzymology·A KnebelP Herrlich
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
May 18, 2001·Trends in Cell Biology·A Ostman, F D Böhmer
Sep 26, 2001·Neoplasia : an International Journal for Oncology Research·S W StollJ T Elder
Nov 9, 2002·The Journal of Biological Chemistry·Fawaz G HajBenjamin G Neel
Mar 25, 2004·Methods in Enzymology·Kotb AbdelmohsenLars-Oliver Klotz
Dec 8, 2004·Cellular and Molecular Life Sciences : CMLS·S MénardE Tagliabue
Jan 18, 2005·Biochemical and Biophysical Research Communications·Ira MelchheierLars-Oliver Klotz
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane

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Citations

Sep 10, 2008·Current Oncology Reports·Benjamin M Solomon, Aminah Jatoi
Jun 25, 2009·PloS One·Sari SuomelaUlpu Saarialho-Kere
Nov 4, 2006·Biological Chemistry·Claudia von MontfortLars-Oliver Klotz
Sep 29, 2011·Annual Review of Pharmacology and Toxicology·Yoshito KumagaiArthur K Cho
Sep 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lars-Oliver KlotzClaus Jacob
Feb 6, 2007·Biochimica Et Biophysica Acta·Kyoko YoshikawaOsamu Hazeki
Jul 18, 2015·Redox Biology·Lars-Oliver KlotzMaria Monsalve
Oct 7, 2006·Free Radical Biology & Medicine·Claudia von MontfortLars-Oliver Klotz
Mar 11, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisanne C AndersJuliane I Beier
Feb 14, 2014·TheScientificWorldJournal·I PinillaF Sopeña
Oct 26, 2016·Toxicology and Applied Pharmacology·Lisanne C AndersJuliane I Beier
Jan 24, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R-D HofheinzK Merx
Mar 23, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M E Lacouture
Feb 16, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jesper Grau EriksenPer Pfeiffer
Dec 24, 2019·Frontiers in Genetics·Joanna PyczekHeidi Hahn
Feb 16, 2010·Archives of Biochemistry and Biophysics·Viola KlausLars-Oliver Klotz

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