Activation of ERK, AKT and JNK signalling pathways in human schwannomas in situ

Histopathology
David A HiltonC Oliver Hanemann

Abstract

Schwannomas are common tumours that may be multiple in neurofibromatosis type 2, when they may be difficult to treat without significant morbidity using surgery and radiosurgery. Previous in vitro work has suggested that merlin loss is associated with activation of the JNK/JUN, PI3K/AKT and MEK/ERK pathways and that these pathways may be susceptible to pharmacological inhibition. The aim was to investigate the expression of proteins involved in these pathways in human schwannomas in situ. Immunohistochemistry using antibodies to AKT, pAKT, MEK, pMEK, ERK, pERK, JUN and pJUN was applied to 16 schwannomas (sporadic and NF2), and the results were compared with those seen in traumatic neuromas. Increased expression of pMEK, pERK and pJUN was seen in the schwannomas samples and of pAKT in schwannomas and controls. These findings provide further direct evidence for activation of the JNK/JUN, PI3K/AKT and MEK/ERK signalling pathways in schwannomas and support the development of therapeutic agents directed against these pathways for the treatment of this group of tumours.

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Citations

Jun 8, 2011·Nature Reviews. Neurology·Sylwia Ammoun, C Oliver Hanemann
Jun 1, 2010·Neuro-oncology·Sylwia AmmounMatthias A Karajannis
Apr 22, 2015·Oncogene·A M Petrilli, C Fernández-Valle
Feb 1, 2013·Histopathology·Aditya ShivaneClemens O Hanemann
Jan 24, 2014·Brain Pathology·David A Hilton, Clemens Oliver Hanemann
Jul 4, 2012·Biochimica Et Biophysica Acta·K Adam Morrow, Lalita A Shevde
Apr 17, 2012·Otolaryngologia polska. The Polish otolaryngology·Craig MillerAbraham Jacob
Nov 11, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·David A HiltonC Oliver Hanemann
Jun 5, 2019·Acta Neuropathologica·Shannon CoySandro Santagata
Jul 10, 2020·Neuro-oncology Advances·Sara FerlugaClemens O Hanemann
Mar 20, 2012·Molecular Cancer Research : MCR·Marianne F JamesVijaya Ramesh
Jan 13, 2021·International Journal of Molecular Sciences·Agbolahan A SofelaC Oliver Hanemann
Aug 6, 2021·Journal of Medical Genetics·Núria CatasúsUNKNOWN NF2 Spanish National Reference Centre HUGTP-ICO-IGTP

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