Activation of extracellular signal-related kinases 1 and 2 in Sertoli cells in experimentally cryptorchid rhesus monkeys

Asian Journal of Andrology
Xue-Sen ZhangYi-Xun Liu

Abstract

To assess the spatiotemporal changes in the expression of extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases (JNK) and p38 mitogen-activated protein kinases (MAPK) in response to heat stress in the cryptorchid testis, and to investigate a possible relation to Sertoli cell dedifferentiation. Immunohistochemistry and western blot were used to examine the expression and activation of ERK1/2, p38 and JNK in the cryptorchid testis at various stages after experimental cryptorchidism. The abdominal temperature did not obviously change the total ERK1/2 expression but significantly activated phospho-ERK1/2 in the Sertoli cells of the cryptorchid testis. Heat stress increased total JNK expression in the Sertoli cells of the cryptorchid testis but did not activate phospho-JNK. Neither total p38 nor phospho-p38 was induced by heat stress in the Sertoli cells of the cryptorchid testis. Changes in the spatiotemporal expression of cytokeratin 18 (CK18), a marker of immature or undifferentiated Sertoli cells, were induced in the cryptorchid testis in a pattern similar to the activation of ERK1/2. The activation of ERK1/2 in the testis may be related to dedifferentiation of Sertoli cells under heat stress induced ...Continue Reading

References

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Jul 24, 2004·International Journal of Andrology·Zhi-Hong ZhangYi-Xun Liu
Apr 19, 2005·Endocrinology·Joseph P McGillis

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Citations

Nov 4, 2010·Science China. Life Sciences·YiXun Liu, XiXia Li
Feb 22, 2012·Nature Reviews. Urology·Rajender SinghAshok Agarwal
Sep 14, 2011·Ultrastructural Pathology·Mohamed A Adly, Mahmoud Rezk Abdelwahed Hussein

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