Activation of Fes tyrosine kinase by gp130, an interleukin-6 family cytokine signal transducer, and their association.

The Journal of Biological Chemistry
T MatsudaT Hirano

Abstract

gp130 is a signal-transducing subunit of receptors for the interleukin-6 (IL-6)-related cytokine subfamily including IL-6, leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotrophic factor, indicating that gp130-mediated signals are involved in the immune response, hematopoiesis, inflammation, and endocrine and nervous system activity. We previously showed that gp130 stimulation rapidly activates Jak, Btk, and Tec tyrosine kinases, all of which constitutively associate with gp130. To further elucidate intracellular signal transduction through gp130, we examined the possible involvement of another nonreceptor tyrosine kinase, p92c-fes (Fes). We showed that gp130 stimulation rapidly induced tyrosine phosphorylation of Fes and actually activated its kinase activity in hematopoietic lineage cells. Furthermore, Fes associated with gp130 independently of ligand stimulation like Jak, Btk, and Tec tyrosine kinases. These results indicate that multiple nonreceptor tyrosine kinases are involved in the gp130-mediated signal transduction pathway. Because both gp130 and Fes are expressed not only in hematopoietic lineage cells but also in heart and nerve cells, Fes may play a role in signal transduction through gp130 in these...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M MurakamiT Kishimoto
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S P YeeT Pawson
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R A FeldmanH Hanafusa
Jul 15, 1994·Biochemical and Biophysical Research Communications·L C BergerR G Hawley
Jul 29, 1994·Biochemical and Biophysical Research Communications·Y FujitaniT Hirano
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·D PennicaK R Chien
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M NarazakiT Taga
Apr 29, 1994·Biochemical and Biophysical Research Communications·T MatsudaT Hirano

❮ Previous
Next ❯

Citations

Aug 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y WangH Baumann
Aug 30, 2003·Current Pain and Headache Reports·Mollie E Thompson, André Barkhuizen
Dec 10, 2003·Experimental Hematology·Waheed SangrarPeter A Greer
Sep 29, 1998·Biochemical Pharmacology·F M Uckun
Aug 7, 2003·Experimental Hematology·Yotis A SenisPeter A Greer
Mar 3, 1998·Critical Reviews in Oncology/hematology·L M TuytE Vellenga
May 1, 1997·The International Journal of Biochemistry & Cell Biology·A R GendallM Ernst
Jun 10, 1998·Cytokine & Growth Factor Reviews·T HiranoM Hibi
Apr 1, 2000·Cytokine & Growth Factor Reviews·P M GrimleyH Rui
Jan 5, 2000·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·S YasudaA Kakizuka
Sep 4, 2010·Antioxidants & Redox Signaling·Jennifer N Earley, John J Turchi
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·J LosmanP Rothman
Apr 21, 2001·Molecular and Cellular Biology·D W Kim, B H Cochran
Mar 23, 2002·Molecular and Cellular Biology·Ralph A ZirngiblPeter A Greer
Jan 1, 1996·Annual Review of Cell and Developmental Biology·S S WatowichH F Lodish
Jan 1, 1997·Annual Review of Immunology·J B Bolen, J S Brugge
Jan 1, 1997·Annual Review of Physiology·M B BurgD Kültz
May 3, 2000·Clinical and Experimental Immunology·H B GasparT Espanol
Mar 3, 2009·Expert Opinion on Emerging Drugs·Klaus PodarKenneth C Anderson
Oct 27, 2004·Experimental Hematology·Waheed SangrarPeter A Greer
Nov 17, 2001·The Journal of Investigative Dermatology·M GarmynD Maes
Jul 20, 2005·Best Practice & Research. Clinical Haematology·Teru HideshimaKenneth C Anderson
Mar 20, 1998·International Reviews of Immunology·T Hirano
Mar 20, 1998·International Reviews of Immunology·J L TaupinJ F Moreau
May 17, 2001·BMC Immunology·M ChamorroP L Schwartzberg
Jun 6, 2006·The Journal of Allergy and Clinical Immunology·Rebeca Pérez de DiegoSusana Alemany
Apr 16, 2009·Critical Reviews in Biochemistry and Molecular Biology·Derek J RichardKum Kum Khanna
May 29, 2002·Oncogene·Blanca Scheijen, James D Griffin

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.