Activation of fibroblast and papilla cells by glycolipid biosurfactants, mannosylerythritol lipids

Journal of Oleo Science
Tomotake MoritaDai Kitamoto

Abstract

Mannosylerythritol lipids (MELs), the extracellular glycolipids produced from feedstock by yeasts belonging to the genus Pseudozyma, are the most promising biosurfactants known due to its versatile interfacial and biochemical actions. In order to broaden the application in cosmetics, the cell activating property of MELs was investigated using cultured fibroblast and papilla cells, and a three-dimensional cultured human skin model. The di-acetylated MEL (MEL-A) produced from soybean oil significantly increased the viability of the fibroblast cells over 150% compared with that of control cells. On the other hand, no cell activation was observed by the treatment with MEL-A produced from olive oil. The mono-acetylated MEL (MEL-B) hardly increased the cell viability. The viability of the fibroblast cells decreased with the addition of more than 1 microg/L of MELs, whereas the cultured human skin cells showed high viability with 5 microg/L of MELs. Interestingly, the papilla cells were dramatically activated with 0.001 microg/L of MEL-A produced from soybean oil: the cell viability reached at 150% compared with that of control cells. Consequently, the present MEL-A produced from soybean oil should have a potential as a new hair growt...Continue Reading

References

Aug 12, 1999·The New England Journal of Medicine·R Paus, G Cotsarelis
Mar 5, 2004·The British Journal of Dermatology·A G Messenger, J Rundegren
Apr 4, 2009·Biotechnology and Applied Biochemistry·Tomotake MoritaDai Kitamoto
May 1, 2010·Journal of Oleo Science·Tomotake MoritaDai Kitamoto

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Citations

Apr 16, 2013·Applied Microbiology and Biotechnology·Tomotake MoritaDai Kitamoto
Apr 26, 2012·Journal of Oleo Science·Tokuma FukuokaDai Kitamoto
Feb 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yi-Shyan ChenChih-Chien Lin
Mar 12, 2011·Journal of Bioscience and Bioengineering·Masaaki KonishiYuji Hatada
Mar 10, 2015·Journal of Oleo Science·Tomotake MoritaDai Kitamoto
Apr 22, 2015·Journal of Oleo Science·Tokuma FukuokaHiroko Kitamoto
Sep 11, 2012·Microbiological Research·Alejandro de Jesús Cortés-SánchezMaría Eugenia Jaramillo-Flores
Nov 16, 2018·Journal of Oleo Science·Tokuma FukuokaHiroshi Habe
May 15, 2015·Letters in Applied Microbiology·A Varvaresou, K Iakovou

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