Activation of Functional Brain Networks in Children With Psychogenic Non-epileptic Seizures.

Frontiers in Human Neuroscience
Mohammadreza RadmaneshKasia Kozlowska

Abstract

Psychogenic non-epileptic seizures (PNES) have been hypothesized to emerge in the context of neural networks instability. To explore this hypothesis in children, we applied a graph theory approach to examine connectivity in neural networks in the resting-state EEG in 35 children with PNES, 31 children with other functional neurological symptoms (but no PNES), and 75 healthy controls. The networks were extracted from Laplacian-transformed time series by a coherence connectivity estimation method. Children with PNES (vs. controls) showed widespread changes in network metrics: increased global efficiency (gamma and beta bands), increased local efficiency (gamma band), and increased modularity (gamma and alpha bands). Compared to controls, they also had higher levels of autonomic arousal (e.g., lower heart variability); more anxiety, depression, and stress on the Depression Anxiety and Stress Scales; and more adverse childhood experiences on the Early Life Stress Questionnaire. Increases in network metrics correlated with arousal. Children with other functional neurological symptoms (but no PNES) showed scattered and less pronounced changes in network metrics. The results indicate that children with PNES present with increased acti...Continue Reading

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Citations

May 25, 2021·Epilepsy Currents·M Scott Perry, Christos Papadelis
Oct 30, 2021·The Journal of Neuropsychiatry and Clinical Neurosciences·Sara Paredes-EcheverriDavid L Perez

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