PMID: 8945968Nov 1, 1996Paper

Activation of GABAB receptors increases a potassium conductance in rat bulbospinal neurons of the C1 area

The American Journal of Physiology
Y W Li, P G Guyenet

Abstract

In anesthetized rats, iontophoresis of the gamma-aminobutyric acid (GABAB)-receptor agonist and antispastic drug baclofen inhibits the bulbospinal vasomotor neurons of the rostral ventrolateral medulla (RVLM). The present study was carried out to determine whether C1 adrenergic and other bulbospinal neurons of the RVLM have postsynaptic GABAB receptors. Retrogradely labeled RVLM bulbospinal neurons (n = 52) were recorded in 120-micron-thick slices from neonatal rat brain (3-10 days old). Most neurons (48/52) were tonically active (3 +/- 0.6 spikes/s). Twenty-six neurons were recovered histologically, and 18 of them were immunoreactive for tyrosine hydroxylase (TH). In current clamp, baclofen (0.3-10 microM) hyperpolarized RVLM bulbospinal cells in a dose-dependent manner (16 +/- 0.5 mV hyperpolarization by 3 microM baclofen; n = 19) and decreased input resistance by 40% (n = 10). In voltage clamp (1 microM tetrodotoxin present; holding potential: -40 to -60 mV), 3 microM baclofen induced an outward current of 21 +/- 2 pA (n = 29). This current exhibited inward rectification and reversed polarity close to the K+ equilibrium potential (external K+ from 2.5 to 10 mM). The current induced by baclofen was reduced 90% by 0.1-0.2 mM B...Continue Reading

Citations

Jul 2, 2015·The Journal of Comparative Neurology·Lama Bou FarahSimon McMullan
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kun ZhangKaushik P Patel
Jul 23, 2005·Journal of Applied Physiology·Yi-Wen ChengChun-Kuei Su

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