Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives

European Journal of Oral Sciences
Yoshihiro NishitaniDavid H Pashley

Abstract

Mild acids are known to activate dentin matrix metalloproteinase (MMPs). All self-etching dental adhesives are acidic (pH 1.5-2.7) and may activate dentin MMPs. The purpose of this study was to compare the ability of several all-in-one adhesives to activate gelatinolytic and collagenolytic activities in powdered mineralized dentin. Powdered dentin made from human teeth was mixed with all-in-one adhesives (Clearfil Tri-S Bond, G-Bond, Adper Prompt L-Pop) or a self-etching primer (Clearfil SE Bond primer) for varying times and then the reaction was stopped by extracting the adhesives using acetone. Fresh untreated mineralized dentin powder had a gelatinolytic activity of 3.31 +/- 0.39 relative fluorescent units (RFU) per mg dry weight (24 h) that increased, over storage time, to 87.5 RFU mg(-1) (24 h) after 6-8 wk. When fresh powder was treated with acidic Tri-S Bond, the gelatinolytic activity increased from 3.24 +/- 0.70 RFU mg(-1) to > 112.5 RFU mg(-1) (24 h) after 20 min and then remained unchanged. Monomers with lower pH values produced less activity. There was a significant, direct correlation between gelatinolytic activity and pH, with Tri-S giving the highest activity. Coating dentin powder with Tri-S resin prevented fluo...Continue Reading

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Citations

Jun 15, 2007·Journal of Materials Science. Materials in Medicine·Manuel ToledanoFranklin Tay
Aug 7, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Annalisa MazzoniLorenzo Breschi
Aug 21, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Leo TjäderhaneDavid H Pashley
May 8, 2013·Journal of Biomaterials Science. Polymer Edition·Salvatore SauroManuel Toledano
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Mar 5, 2010·Journal of Dental Research·J KimF R Tay
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Aug 21, 2012·Dental Materials : Official Publication of the Academy of Dental Materials·Leo TjäderhaneDavid H Pashley
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Jun 17, 2011·Dental Materials : Official Publication of the Academy of Dental Materials·Arzu Tezvergil-MutluayDavid H Pashley
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Mar 20, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·Lorenzo BreschiDavid H Pashley
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Jan 5, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·Lorenzo BreschiDavid H Pashley
May 5, 2009·Journal of Endodontics·Juliana SantosLeo Tjäderhane

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